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Neutralization of SARS-CoV-2 Variants by rVSV-ΔG-Spike-Elicited Human Sera. 2022
Yfat Yahalom-Ronen, and
Noam Erez, and
Morly Fisher, and
Hadas Tamir, and
Boaz Politi, and
Hagit Achdout, and
Sharon Melamed, and
Itai Glinert, and
Shay Weiss, and
Inbar Cohen-Gihon, and
Ofir Israeli, and
Marina Izak, and
Michal Mandelboim, and
Yoseph Caraco, and
Noa Madar-Balakirski, and
Adva Mechaly, and
Eilat Shinar, and
Ran Zichel, and
Daniel Cohen, and
Adi Beth-Din, and
Anat Zvi, and
Hadar Marcus, and
Tomer Israely, and
Nir Paran
Department of Infectious Diseases, Israel Institute for Biological Research, Ness Ziona 7410001, Israel.
The emergence of rapidly spreading variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a major challenge to the ability of vaccines and therapeutic antibodies to provide immunity. These variants contain mutations of specific amino acids that might impede vaccine efficacy. BriLife® (rVSV-ΔG-spike) is a newly developed SARS-CoV-2 vaccine candidate currently in phase II clinical trials. It is based on a replication-competent vesicular stomatitis virus (VSV) platform. The rVSV-ΔG-spike contains several spontaneously acquired spike mutations that correspond to SARS-CoV-2 variants' mutations. We show that human sera from BriLife® vaccinees preserve comparable neutralization titers towards alpha, gamma, and delta variants and show less than a three-fold reduction in the neutralization capacity of beta and omicron compared to the original virus. Taken together, we show that human sera from BriLife® vaccinees overall maintain a neutralizing antibody response against all tested variants. We suggest that BriLife®-acquired mutations may prove advantageous against future SARS-CoV-2 VOCs.
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