Phytophthora sojae and soybean cyst nematode (SCN) are important pathogens of soybean. Although these pathogens infect soybean roots, there is limited evidence of any interaction between them. The objective of this study was to examine the interaction between SCN and P. sojae on soybean in the greenhouse. Seeds of four soybean cultivars (Jack, Surge, Williams 82, Williams) were pre-germinated and placed in cone-tainers (Stuewe and Sons Inc., Tangent, OR, USA), containing a steam pasteurized sand-clay mixture. The experiment was set up in a completely randomized design with five replications and performed twice. Two P. sojae isolates were used in this study that represented two different virulence pathotypes (simple and complex pathotypes). For each isolate, soybean plants were not inoculated, inoculated with one of the treatments-SCN, P. sojae, and combination of P. sojae and SCN. After 35 DOI, stem length, root length, plant weight, root weight, lesion length, and SCN population were recorded. On all soybean cultivars with different types of incomplete resistance, the complex pathotype (PS-15-TF3) influenced the lesion length (mm) in the presence of SCN. However, the SCN population was reduced by both complex and simple pathotypes of P. sojae. This suggests that use both SCN and P. sojae resistance cultivars, can manage the disease complex and reduce soybean yield loss.