Biomaterial Database

Severe intrauterine growth retardation; assessment of its origin from fetal arterial flow velocity waveforms. 1986

J W Wladimiroff, and H M Tonge, and P A Stewart, and A Reuss

Doppler blood flow velocity waveforms in the umbilical artery and fetal internal carotid artery were recorded in a total of 10 patients with severe intrauterine growth retardation (IUGR) and marked oligohydramnios to establish a fetal or utero-placental origin of IUGR. Gestational age varied between 28 and 37 wk. Negative maternal serology ruled out fetal infections. In six patients, IUGR was associated with abnormal flow velocity waveforms, indicating utero-placental insufficiency. Following delivery, these infants showed no structural defects; moderate to marked placental infarction was documented in 4 out of 6 cases. In the remaining four patients, IUGR was associated with normal flow velocity waveforms, suggesting a fetal origin of the IUGR. Following delivery, all four infants revealed structural defects, only one of which was diagnosed prenatally. Twice an abnormal karyotype was the underlying cause. There was no placental infarction. These preliminary data suggest that combined recording of the flow velocity waveform in the above-mentioned vessels may provide valuable additional information as to the cause of IUGR and as such be helpful in determining obstetric management.

UI	MeSH Term	Description	Entries
D007231	Infant, Newborn	An infant during the first 28 days after birth.	Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D007238	Infarction	Formation of an infarct, which is NECROSIS in tissue due to local ISCHEMIA resulting from obstruction of BLOOD CIRCULATION, most commonly by a THROMBUS or EMBOLUS.	Infarct,Infarctions,Infarcts
D008297	Male		Males
D010920	Placenta	A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).	Placentoma, Normal,Placentome,Placentas,Placentomes
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D001783	Blood Flow Velocity	A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.	Blood Flow Velocities,Flow Velocities, Blood,Flow Velocity, Blood,Velocities, Blood Flow,Velocity, Blood Flow
D005260	Female		Females
D005317	Fetal Growth Retardation	Failure of a FETUS to attain expected GROWTH.	Growth Retardation, Intrauterine,Intrauterine Growth Retardation,Fetal Growth Restriction,Intrauterine Growth Restriction
D005333	Fetus	The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN.	Fetal Structures,Fetal Tissue,Fetuses,Mummified Fetus,Retained Fetus,Fetal Structure,Fetal Tissues,Fetus, Mummified,Fetus, Retained,Structure, Fetal,Structures, Fetal,Tissue, Fetal,Tissues, Fetal
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man