-transparent.png){kind=logo}
We have studied the intrauterine development of guinea pig and rat organ phosphatases using biochemical, immunologic, and histologic techniques. In all organs tested the features of the adult phosphatase activity were achieved during the second or third gestational phases. In the rat, the tissue-unspecific phosphatase activity was found by immunoprecipitation with antiserum to rat liver phosphatase in all gestational phases in liver and placenta. The high liver activity in the first phase of gestation corresponded to hematopoietic cells. Hepatocyte phosphatase did not appear until the second gestational phase. The tissue-unspecific phosphatase activity was found in the first and second gestational phase in surface intestinal epithelial cells, even after crypt formation occurred. Once phosphatase appeared in enterocytes on villi, only the intestinal-type enzyme was detected. Alkaline phosphatase was measured in the liver and intestine from animals in various phyla. In fish and reptiles, the intestinal activity had the enzymatic characteristics of the tissue-unspecific enzyme. The appearance of intestinal alkaline phosphatase with unique properties and high specific activity is a characteristic of mammals.
T Komoda, and
I Koyama, and
A Nagata, and
Y Sakagishi, and
K DeSchryver-Kecskemeti, and
D H Alpers
October 1969,
Annals of the New York Academy of Sciences,
T Komoda, and
I Koyama, and
A Nagata, and
Y Sakagishi, and
K DeSchryver-Kecskemeti, and
D H Alpers
January 1950,
Bulletin de la Societe de chimie biologique,
T Komoda, and
I Koyama, and
A Nagata, and
Y Sakagishi, and
K DeSchryver-Kecskemeti, and
D H Alpers
July 1986,
Clinica chimica acta; international journal of clinical chemistry,
T Komoda, and
I Koyama, and
A Nagata, and
Y Sakagishi, and
K DeSchryver-Kecskemeti, and
D H Alpers
December 1978,
Srpski arhiv za celokupno lekarstvo,
T Komoda, and
I Koyama, and
A Nagata, and
Y Sakagishi, and
K DeSchryver-Kecskemeti, and
D H Alpers
June 1971,
Clinica chimica acta; international journal of clinical chemistry,
T Komoda, and
I Koyama, and
A Nagata, and
Y Sakagishi, and
K DeSchryver-Kecskemeti, and
D H Alpers
September 1972,
European journal of biochemistry,
T Komoda, and
I Koyama, and
A Nagata, and
Y Sakagishi, and
K DeSchryver-Kecskemeti, and
D H Alpers
January 1990,
Clinica chimica acta; international journal of clinical chemistry,
T Komoda, and
I Koyama, and
A Nagata, and
Y Sakagishi, and
K DeSchryver-Kecskemeti, and
D H Alpers
May 1976,
The Journal of biological chemistry,
T Komoda, and
I Koyama, and
A Nagata, and
Y Sakagishi, and
K DeSchryver-Kecskemeti, and
D H Alpers
December 1975,
Clinica chimica acta; international journal of clinical chemistry,
T Komoda, and
I Koyama, and
A Nagata, and
Y Sakagishi, and
K DeSchryver-Kecskemeti, and
D H Alpers
September 1978,
American journal of veterinary research,
