Biomaterial Database

Experimental pulmonary edema: the effect of positive end-expiratory pressure on lung water. 1978

C E Bredenberg, and T Kazui, and W R Webb

The effect of 10 cm of positive end-expiratory pressure (PEEP) on lung water was studied during pulmonary edema induced in dogs by inflating a Foley balloon placed in the left atrium. Colloid oncotic pressure (COP) was measured directly. Intrapleural pressure (IPP) was measured after surgical closure of the chest. Transmural left atrial (LA) pressure (LA minus IPP) minus COP was considered to be the net force driving water out of the capillaries. LA pressure was elevated so that transmural LA pressure minus COP averaged +7.5 mm Hg. Water accumulation was expressed as the ratio of wet to dry weight. The control ratio of wet to dry lung weight was 4.30 +/- 0.10 (+/- SE). After 2 hours of standardized pulmonary edema and ventilation without PEEP, wet-to-dry lung weight was 5.63 +/- 0.24. In animals ventilated with 10 cm of PEEP through 2 hours of pulmonary edema the ratio was 5.36 +/- 0.14. Animals ventilated with 10 cm of PEEP showed a significant increase in functional residual capacity and decreased intrapulmonary shunt. Ten centimeters of PEEP, however, had no statistically significant effect on water accumulation during experimental pulmonary edema.

UI	MeSH Term	Description	Entries
D008168	Lung	Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.	Lungs
D009929	Organ Size	The measurement of an organ in volume, mass, or heaviness.	Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D011175	Positive-Pressure Respiration	A method of mechanical ventilation in which pressure is maintained to increase the volume of gas remaining in the lungs at the end of expiration, thus reducing the shunting of blood through the lungs and improving gas exchange.	Positive End-Expiratory Pressure,Positive-Pressure Ventilation,End-Expiratory Pressure, Positive,End-Expiratory Pressures, Positive,Positive End Expiratory Pressure,Positive End-Expiratory Pressures,Positive Pressure Respiration,Positive Pressure Ventilation,Positive-Pressure Respirations,Positive-Pressure Ventilations,Pressure, Positive End-Expiratory,Pressures, Positive End-Expiratory,Respiration, Positive-Pressure,Respirations, Positive-Pressure,Ventilation, Positive-Pressure,Ventilations, Positive-Pressure
D011654	Pulmonary Edema	Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.	Wet Lung,Edema, Pulmonary,Edemas, Pulmonary,Pulmonary Edemas,Lung, Wet,Lungs, Wet,Wet Lungs
D012115	Residual Volume	The volume of air remaining in the LUNGS at the end of a maximal expiration. Common abbreviation is RV.	Residual Volumes,Volume, Residual,Volumes, Residual
D001834	Body Water	Fluids composed mainly of water found within the body.	Water, Body
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia