Burnout in nurses can have negative consequences for the organizational health of the institution and the mental and physical health of the nurse. In this article, the authors identify the incidence of burnout in nursing and risk and protective factors. Next, they discuss the relationship between burnout and health, highlighting the critical relationship between burnout, stress, inflammation, and declines in physical health. Lastly, they review articles from the Zangaro and colleagues' systematic review related to mental and physical health to create a picture of the existing research on burnout and health.