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Human Fecal Microbiota Transplantation Reduces the Susceptibility to Dextran Sulfate Sodium-Induced Germ-Free Mouse Colitis. 2022

Yapeng Yang, and Xiaojiao Zheng, and Yuqing Wang, and Xiang Tan, and Huicong Zou, and Shuaifei Feng, and Hang Zhang, and Zeyue Zhang, and Jinhui He, and Bota Cui, and Xueying Zhang, and Zhifeng Wu, and Miaomiao Dong, and Wei Cheng, and Shiyu Tao, and Hong Wei
College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, China.

In clinical practice, fecal microbiota transplantation (FMT) has been used to treat inflammatory bowel disease (IBD), and has shown certain effects. However, the selection of FMT donors and the mechanism underlying the effect of FMT intervention in IBD require further exploration. In this study, dextran sodium sulfate (DSS)-induced colitis mice were used to determine the differences in the protection of colitis symptoms, inflammation, and intestinal barrier, by FMT from two donors. Intriguingly, pre-administration of healthy bacterial fluid significantly relieved the symptoms of colitis compared to the ulcerative colitis (UC) bacteria. In addition, healthy donor (HD) bacteria significantly reduced the levels of inflammatory markers Myeloperoxidase (MPO) and Eosinophil peroxidase (EPO), and various pro-inflammatory factors, in colitis mice, and increased the secretion of the anti-inflammatory factor IL-10. Metagenomic sequencing indicated higher species diversity and higher abundance of anti-inflammatory bacteria in the HD intervention group, including Alistipes putredinis, Akkermansia muciniphila, Bifidobacterium adolescentis, short-chain fatty acids (SCFAs)-producing bacterium Christensenella minuta, and secondary bile acids (SBAs)-producing bacterium Clostridium leptum. In the UC intervention group, the SCFA-producing bacterium Bacteroides stercoris, IBD-related bacterium Ruminococcus gnavus, Enterococcus faecalis, and the conditional pathogen Bacteroides caccae, were more abundant. Metabolomics analysis showed that the two types of FMT significantly modulated the metabolism of DSS-induced mice. Moreover, compared with the UC intervention group, indoleacetic acid and unsaturated fatty acids (DHA, DPA, and EPA) with anti-inflammatory effects were significantly enriched in the HD intervention group. In summary, these results indicate that FMT can alleviate the symptoms of colitis, and the effect of HD intervention is better than that of UC intervention. This study offers new insights into the mechanisms of FMT clinical intervention in IBD.

UI MeSH Term Description Entries
D003092 Colitis Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER. Colitides
D003093 Colitis, Ulcerative Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN. Colitis Gravis,Idiopathic Proctocolitis,Inflammatory Bowel Disease, Ulcerative Colitis Type,Ulcerative Colitis
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000069196 Gastrointestinal Microbiome All of the microbial organisms that naturally exist within the GASTROINTESTINAL TRACT. Enteric Bacteria,Gastric Microbiome,Gastrointestinal Flora,Gastrointestinal Microbial Community,Gastrointestinal Microbiota,Gastrointestinal Microflora,Gut Flora,Gut Microbiome,Gut Microbiota,Gut Microflora,Intestinal Flora,Intestinal Microbiome,Intestinal Microbiota,Intestinal Microflora,Bacteria, Enteric,Flora, Gastrointestinal,Flora, Gut,Flora, Intestinal,Gastric Microbiomes,Gastrointestinal Microbial Communities,Gastrointestinal Microbiomes,Gastrointestinal Microbiotas,Gut Microbiomes,Gut Microbiotas,Intestinal Microbiomes,Intestinal Microbiotas,Microbial Community, Gastrointestinal,Microbiome, Gastric,Microbiome, Gastrointestinal,Microbiome, Gut,Microbiome, Intestinal,Microbiota, Gastrointestinal,Microbiota, Gut,Microbiota, Intestinal,Microflora, Gastrointestinal,Microflora, Gut,Microflora, Intestinal
D000069467 Fecal Microbiota Transplantation Transfer of GASTROINTESTINAL MICROBIOTA from one individual to another by infusion of donor FECES to the upper or lower GASTROINTESTINAL TRACT of the recipient. Fecal Microbiome Transplantation,Fecal Microbiota Transfer,Fecal Microbiota Transplant,Intestinal Microbiome Transfer,Intestinal Microbiome Transplant,Intestinal Microbiome Transplantation,Intestinal Microbiota Transplant,Intestinal Microbiota Transplantation,Donor Feces Infusion,Fecal Transplant,Fecal Transplantation,Intestinal Microbiota Transfer,Donor Feces Infusions,Fecal Microbiome Transplantations,Fecal Microbiota Transfers,Fecal Microbiota Transplantations,Fecal Microbiota Transplants,Fecal Transplantations,Fecal Transplants,Feces Infusion, Donor,Feces Infusions, Donor,Infusion, Donor Feces,Infusions, Donor Feces,Intestinal Microbiome Transfers,Intestinal Microbiome Transplantations,Intestinal Microbiome Transplants,Intestinal Microbiota Transfers,Intestinal Microbiota Transplantations,Intestinal Microbiota Transplants,Microbiome Transfer, Intestinal,Microbiome Transfers, Intestinal,Microbiome Transplant, Intestinal,Microbiome Transplantation, Fecal,Microbiome Transplantation, Intestinal,Microbiome Transplantations, Fecal,Microbiome Transplantations, Intestinal,Microbiome Transplants, Intestinal,Microbiota Transfer, Fecal,Microbiota Transfer, Intestinal,Microbiota Transfers, Fecal,Microbiota Transfers, Intestinal,Microbiota Transplant, Fecal,Microbiota Transplant, Intestinal,Microbiota Transplantation, Fecal,Microbiota Transplantation, Intestinal,Microbiota Transplantations, Fecal,Microbiota Transplantations, Intestinal,Microbiota Transplants, Fecal,Microbiota Transplants, Intestinal,Transfer, Fecal Microbiota,Transfer, Intestinal Microbiome,Transfer, Intestinal Microbiota,Transfers, Fecal Microbiota,Transfers, Intestinal Microbiome,Transfers, Intestinal Microbiota,Transplant, Fecal,Transplant, Fecal Microbiota,Transplant, Intestinal Microbiome,Transplant, Intestinal Microbiota,Transplantation, Fecal,Transplantation, Fecal Microbiome,Transplantation, Fecal Microbiota,Transplantation, Intestinal Microbiome,Transplantation, Intestinal Microbiota,Transplantations, Fecal,Transplantations, Fecal Microbiome,Transplantations, Fecal Microbiota,Transplantations, Intestinal Microbiome,Transplantations, Intestinal Microbiota,Transplants, Fecal,Transplants, Fecal Microbiota,Transplants, Intestinal Microbiome,Transplants, Intestinal Microbiota
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000893 Anti-Inflammatory Agents Substances that reduce or suppress INFLAMMATION. Anti-Inflammatory Agent,Antiinflammatory Agent,Agents, Anti-Inflammatory,Agents, Antiinflammatory,Anti-Inflammatories,Antiinflammatories,Antiinflammatory Agents,Agent, Anti-Inflammatory,Agent, Antiinflammatory,Agents, Anti Inflammatory,Anti Inflammatories,Anti Inflammatory Agent,Anti Inflammatory Agents
D001419 Bacteria One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive. Eubacteria
D016264 Dextran Sulfate Long-chain polymer of glucose containing 17-20% sulfur. It has been used as an anticoagulant and also has been shown to inhibit the binding of HIV-1 to CD4-POSITIVE T-LYMPHOCYTES. It is commonly used as both an experimental and clinical laboratory reagent and has been investigated for use as an antiviral agent, in the treatment of hypolipidemia, and for the prevention of free radical damage, among other applications. Sodium Dextran Sulfate,Dextran Sulfate Sodium,Dextran Sulfate, Sodium,Sulfate Sodium, Dextran,Sulfate, Dextran,Sulfate, Sodium Dextran
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

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