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The complete amino acid sequence of human von Willebrand factor (vWF) is presented. Most of the sequence was determined by analysis of the S-carboxymethylated protein. Some overlaps not provided by the protein sequence analysis were obtained from the sequence predicted by the nucleotide sequence of a cDNA clone [Sadler, J.E., Shelton-Inloes, B.B., Sorace, J., Harlan, M., Titani, K., & Davie, E.W. (1985) Proc. Natl. Acad. Sci. U.S.A. 82, 6391-6398]. The protein is composed of 2050 amino acid residues containing 12 Asn-linked and 10 Thr/Ser-linked oligosaccharide chains. One of the carbohydrate chains is linked to an Asn residue in the sequence Asn-Ser-Cys rather than the usual Asn-X-Ser/Thr sequence. The sequence of von Willebrand factor includes several regions bearing evidence of internal gene duplication of ancestral sequences. The protein also contains the tetrapeptide sequence Arg-Gly-Asp-Ser (at residues 1744-1747), which may be a cell attachment site, as in fibronectin. The amino- and carboxyl-terminal regions of the molecule contain clusters of half-cystinyl residues. The sequence is unique except for some homology to human complement factor B.
K Titani, and
S Kumar, and
K Takio, and
L H Ericsson, and
R D Wade, and
K Ashida, and
K A Walsh, and
M W Chopek, and
J E Sadler, and
K Fujikawa
September 2001,
Blood,
K Titani, and
S Kumar, and
K Takio, and
L H Ericsson, and
R D Wade, and
K Ashida, and
K A Walsh, and
M W Chopek, and
J E Sadler, and
K Fujikawa
August 1987,
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K Titani, and
S Kumar, and
K Takio, and
L H Ericsson, and
R D Wade, and
K Ashida, and
K A Walsh, and
M W Chopek, and
J E Sadler, and
K Fujikawa
November 1987,
The Tokai journal of experimental and clinical medicine,
K Titani, and
S Kumar, and
K Takio, and
L H Ericsson, and
R D Wade, and
K Ashida, and
K A Walsh, and
M W Chopek, and
J E Sadler, and
K Fujikawa
April 1987,
Biochemical and biophysical research communications,
K Titani, and
S Kumar, and
K Takio, and
L H Ericsson, and
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K Ashida, and
K A Walsh, and
M W Chopek, and
J E Sadler, and
K Fujikawa
January 1988,
Haemostasis,
K Titani, and
S Kumar, and
K Takio, and
L H Ericsson, and
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K Ashida, and
K A Walsh, and
M W Chopek, and
J E Sadler, and
K Fujikawa
October 1985,
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K Titani, and
S Kumar, and
K Takio, and
L H Ericsson, and
R D Wade, and
K Ashida, and
K A Walsh, and
M W Chopek, and
J E Sadler, and
K Fujikawa
July 2012,
Blood,
K Titani, and
S Kumar, and
K Takio, and
L H Ericsson, and
R D Wade, and
K Ashida, and
K A Walsh, and
M W Chopek, and
J E Sadler, and
K Fujikawa
September 1982,
Biochemical and biophysical research communications,
K Titani, and
S Kumar, and
K Takio, and
L H Ericsson, and
R D Wade, and
K Ashida, and
K A Walsh, and
M W Chopek, and
J E Sadler, and
K Fujikawa
November 1987,
Experimental hematology,
K Titani, and
S Kumar, and
K Takio, and
L H Ericsson, and
R D Wade, and
K Ashida, and
K A Walsh, and
M W Chopek, and
J E Sadler, and
K Fujikawa
May 2022,
Haemophilia : the official journal of the World Federation of Hemophilia,
