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About 80% of patients with breast cancer ultimately die of metastatic disease at 20 years. Distant metastases are more important as a cause of death than local or regional relapses. It is for this reason that adjuvant chemotherapy is necessary, especially in young patients and those with extensive disease. Initial chemotherapy preceding any local or regional treatment is justified on the grounds that both surgery and anaesthesia lead to immunodepression. Further, the value of initial chemotherapy has been demonstrated in many experimental and clinical trials by Nissen-Meyer, Bonadonna and Cooper (1-3). In the present study 145 patients, including 67 with inflammatory breast cancer (IBC), were treated with 4-6 weeks of Velbe, thiotepa, methotrexate, fluorouracil and prednisone, with Adriblastin added for patients with IBC, T greater than 7 cm, or N2, N3. Because of tumour regression of greater than 50% observed in 80% of the patients, the majority (123 patients) then received radiotherapy alone (cobalt + iridium), resulting in complete remission in all these cases. Maintenance treatment with the same drugs was prescribed for 6-18 months depending on the initial stage. Tumour regression appears to be an important prognostic factor. Median follow-up is only 17 months, the longest being 42 months. Overall survival at 2 years for IBC is 90%, with a disease-free survival of 80%. Cosmetic results are excellent. While these results are encouraging, longer follow-up is needed to confirm this improvement.
C Jacquillat, and
F Baillet, and
G Auclerc, and
D Khayat, and
J Blondon, and
M F Auclerc, and
T Facchin, and
J P Lefranc, and
M Weil
July 2004,
The American surgeon,
C Jacquillat, and
F Baillet, and
G Auclerc, and
D Khayat, and
J Blondon, and
M F Auclerc, and
T Facchin, and
J P Lefranc, and
M Weil
March 2007,
Zhonghua yi xue za zhi,
C Jacquillat, and
F Baillet, and
G Auclerc, and
D Khayat, and
J Blondon, and
M F Auclerc, and
T Facchin, and
J P Lefranc, and
M Weil
February 2000,
Annals of medicine,
C Jacquillat, and
F Baillet, and
G Auclerc, and
D Khayat, and
J Blondon, and
M F Auclerc, and
T Facchin, and
J P Lefranc, and
M Weil
March 2006,
Nihon rinsho. Japanese journal of clinical medicine,
C Jacquillat, and
F Baillet, and
G Auclerc, and
D Khayat, and
J Blondon, and
M F Auclerc, and
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J P Lefranc, and
M Weil
January 2005,
The British journal of surgery,
C Jacquillat, and
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J P Lefranc, and
M Weil
July 2002,
Oncology (Williston Park, N.Y.),
C Jacquillat, and
F Baillet, and
G Auclerc, and
D Khayat, and
J Blondon, and
M F Auclerc, and
T Facchin, and
J P Lefranc, and
M Weil
January 1991,
European journal of cancer (Oxford, England : 1990),
C Jacquillat, and
F Baillet, and
G Auclerc, and
D Khayat, and
J Blondon, and
M F Auclerc, and
T Facchin, and
J P Lefranc, and
M Weil
August 2004,
Zhonghua zhong liu za zhi [Chinese journal of oncology],
C Jacquillat, and
F Baillet, and
G Auclerc, and
D Khayat, and
J Blondon, and
M F Auclerc, and
T Facchin, and
J P Lefranc, and
M Weil
June 2009,
Expert opinion on pharmacotherapy,
C Jacquillat, and
F Baillet, and
G Auclerc, and
D Khayat, and
J Blondon, and
M F Auclerc, and
T Facchin, and
J P Lefranc, and
M Weil
March 2018,
The Lancet. Oncology,
