Active surveillance of low-risk papillary thyroid microcarcinoma. 2023

Iwao Sugitani
Department of Endocrine Surgery, Nippon Medical School Graduate School of Medicine, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan. Electronic address: isugitani@nms.ac.jp.

Recently, the incidence of thyroid carcinoma has been increasing rapidly worldwide. This is interpreted as an increase in the incidental detection of small papillary thyroid carcinomas by the widespread use of high-resolution imaging techniques such as ultrasonography. However, the mortality rates of thyroid carcinoma have not changed, suggesting that small papillary thyroid carcinomas may be overdiagnosed and overtreated. Active surveillance management has been introduced from Japan since the 1990s, as one of the measures to prevent overtreatment of low-risk papillary thyroid microcarcinoma. Based on the favorable outcomes, active surveillance has been gradually adopted worldwide as an alternative to immediate surgery. The management should be carried out with strict eligibility criteria and close monitoring for cancer progression, under a multidisciplinary team. In addition, an adequate shared decision-making is mandatory for individual patients. Papillary thyroid microcarcinomas with clinically apparent lymph node metastasis, distant metastasis, or invasion to adjacent organs should have surgery.

UI MeSH Term Description Entries
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000077273 Thyroid Cancer, Papillary An ADENOCARCINOMA that originates from follicular cells of the THYROID GLAND and accounts for the majority of THYROID CANCER cases. Cells exhibit enlarged, oval, or elongated morphologies with clear, round, nuclei. Fusions of RET, NTRK1, TPM3, and PCM1 genes are associated with this cancer. Familial Nonmedullary Thyroid Cancer,Nonmedullary Thyroid Carcinoma,Papillary Carcinoma Of Thyroid,Papillary Thyroid Carcinoma,Thyroid Carcinoma, Papillary,Cancer, Papillary Thyroid,Cancers, Papillary Thyroid,Carcinoma, Nonmedullary Thyroid,Carcinoma, Papillary Thyroid,Carcinomas, Nonmedullary Thyroid,Carcinomas, Papillary Thyroid,Nonmedullary Thyroid Carcinomas,Papillary Thyroid Cancer,Papillary Thyroid Cancers,Papillary Thyroid Carcinomas,Thyroid Cancers, Papillary,Thyroid Carcinoma, Nonmedullary,Thyroid Carcinomas, Nonmedullary,Thyroid Carcinomas, Papillary
D013964 Thyroid Neoplasms Tumors or cancer of the THYROID GLAND. Cancer of Thyroid,Thyroid Cancer,Cancer of the Thyroid,Neoplasms, Thyroid,Thyroid Adenoma,Thyroid Carcinoma,Adenoma, Thyroid,Adenomas, Thyroid,Cancer, Thyroid,Cancers, Thyroid,Carcinoma, Thyroid,Carcinomas, Thyroid,Neoplasm, Thyroid,Thyroid Adenomas,Thyroid Cancers,Thyroid Carcinomas,Thyroid Neoplasm
D013965 Thyroidectomy Surgical removal of the thyroid gland. (Dorland, 28th ed) Thyroidectomies
D057832 Watchful Waiting Clinical management approach wherein immediate therapy is not provided but there is a period of observation during which periodic tests monitor patient and the progression of the illness. (Driffield T, Smith PC Med Decis Making. 2007 Mar-Apr;27(2):178-88) Active Surveillance,Expectant Management,Management, Expectant,Surveillance, Active,Waiting, Watchful

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