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Whereas prostaglandin I2 (PGI2), a major metabolite of human lymphatics, does not itself affect lymphatic contractility significantly, it is able to counterbalance the contractile response to thromboxane and leukotrienes. We now demonstrate that leukotrienes C4 and D4 evoke a dose-dependent increased production of PGI2 from human lymphatics. It is likely that leukotrienes either exert a contractile rhythmic effect on human lymphatics or, alternatively, evoke increased PGI2-formation which relaxes human lymphatics. These mechanisms may be of local importance in regulating lymphatic "tone" at sites of inflammation as leukotrienes are liberated from activated white blood cells.
H Sinzinger, and
J Kaliman, and
E Mannheimer
March 1981,
British journal of pharmacology,
H Sinzinger, and
J Kaliman, and
E Mannheimer
October 1987,
Prostaglandins, leukotrienes, and medicine,
H Sinzinger, and
J Kaliman, and
E Mannheimer
November 1992,
British journal of clinical pharmacology,
H Sinzinger, and
J Kaliman, and
E Mannheimer
November 1980,
Acta physiologica Scandinavica,
H Sinzinger, and
J Kaliman, and
E Mannheimer
July 1983,
The British journal of dermatology,
H Sinzinger, and
J Kaliman, and
E Mannheimer
January 1989,
Journal of applied physiology (Bethesda, Md. : 1985),
H Sinzinger, and
J Kaliman, and
E Mannheimer
September 1981,
Life sciences,
H Sinzinger, and
J Kaliman, and
E Mannheimer
July 1986,
Immunology,
H Sinzinger, and
J Kaliman, and
E Mannheimer
May 2009,
Inflammation research : official journal of the European Histamine Research Society ... [et al.],
H Sinzinger, and
J Kaliman, and
E Mannheimer
April 1985,
Prostaglandins,
