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The bacteriophage T4 lysozyme gene is transcribed at early and late times after infection of E. coli, but the early mRNA is not translated. DNA sequence analysis and mapping of the 5' ends of the lysozyme transcripts produced at different times after T4 infection show that the early mRNA is initiated some distance upstream from the gene. The early mRNA is not translated because of a stable secondary structure which blocks the translational initiation site. The stable RNA structure has been demonstrated by nuclease protection in vivo. After DNA replication begins, two late promoters are activated; the late transcripts are initiated at sites such that the secondary structure can not form, and translation of the late messages occurs.
D S McPheeters, and
A Christensen, and
E T Young, and
G Stormo, and
L Gold
November 1976,
The Journal of biological chemistry,
D S McPheeters, and
A Christensen, and
E T Young, and
G Stormo, and
L Gold
January 1973,
Journal of molecular biology,
D S McPheeters, and
A Christensen, and
E T Young, and
G Stormo, and
L Gold
August 1982,
Proceedings of the National Academy of Sciences of the United States of America,
D S McPheeters, and
A Christensen, and
E T Young, and
G Stormo, and
L Gold
November 1978,
Journal of molecular biology,
D S McPheeters, and
A Christensen, and
E T Young, and
G Stormo, and
L Gold
January 1969,
Genetics,
D S McPheeters, and
A Christensen, and
E T Young, and
G Stormo, and
L Gold
January 1968,
The Journal of biological chemistry,
D S McPheeters, and
A Christensen, and
E T Young, and
G Stormo, and
L Gold
July 1981,
Journal of virology,
D S McPheeters, and
A Christensen, and
E T Young, and
G Stormo, and
L Gold
November 1979,
The Journal of general virology,
D S McPheeters, and
A Christensen, and
E T Young, and
G Stormo, and
L Gold
October 1987,
Journal of bacteriology,
D S McPheeters, and
A Christensen, and
E T Young, and
G Stormo, and
L Gold
January 2003,
The international journal of biochemistry & cell biology,
