-transparent.png){kind=logo}
Epididymal fat cells were incubated in vitro with either 2 mM or 6 mM [U-14C]lactate, and where appropriate, 6 mM glucose, 10 mU/ml insulin or 2 micrograms/ml epinephrine. Increasing lactate concentration promoted lactate carbon incorporation into specific products, and the presence of glucose significantly enhanced this effect. Significant lipogenic or lipolytic hormonal effects upon lactate metabolism were observed only in the presence of glucose, as insulin primarily increased lactate conversion to fatty acids while epinephrine promoted lactate oxidation. These data emphasize the importance of lactate as an alternative substrate for intermediary metabolism in adipocytes, and indicate that hormonal modulation of lactate metabolism is modest, but distinct, and requires the presence of physiological glucose concentrations.
D L Crandall, and
A A Francendese, and
M DiGirolamo
March 1976,
The Journal of biological chemistry,
D L Crandall, and
A A Francendese, and
M DiGirolamo
December 1978,
Endocrinology,
D L Crandall, and
A A Francendese, and
M DiGirolamo
March 1993,
The American journal of physiology,
D L Crandall, and
A A Francendese, and
M DiGirolamo
February 1978,
Endokrinologie,
D L Crandall, and
A A Francendese, and
M DiGirolamo
February 1979,
Diabetes,
D L Crandall, and
A A Francendese, and
M DiGirolamo
June 1997,
The American journal of physiology,
D L Crandall, and
A A Francendese, and
M DiGirolamo
February 1988,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
D L Crandall, and
A A Francendese, and
M DiGirolamo
January 1997,
Regulatory peptides,
D L Crandall, and
A A Francendese, and
M DiGirolamo
January 1990,
The American journal of physiology,
D L Crandall, and
A A Francendese, and
M DiGirolamo
January 1983,
Journal of animal science,
