-transparent.png){kind=logo}
Intracellular development of DNA-containing cd phage in the presence of O-methylhydroxylamine (in vivo mutagenesis) results in 50-fold increase of mutants in the phage progeny. The main effect is due to the mutagen presence during replication of phage DNA (within 10-20 min after the infection). The presence of the mutagen both before and after DNA replication does not produce any considerable mutagenic effect. Comparison of the data obtained with kinetic reaction of O-methylhydroxylamine with nucleic acid components is due to enzymatic formation of modified precursors, N4-metoxycytidine and/or N6-metoxyadenosine derivatives, which have dual functional specificity, and to their incorporation into genome under DNA replication. The presence of O-methylhydroxylamine increases not only the number of mixed clones with a high content of mutants, but also the number of pure mutant clones. Recombinogenic activity of O-methylhydroxylamine is considered to be a possible cause of this effect.
E S Preobrazhenskaia, and
L M Klebanova, and
E I Budovskiĭ, and
A S Kriviskiĭ
January 1976,
Genetika,
E S Preobrazhenskaia, and
L M Klebanova, and
E I Budovskiĭ, and
A S Kriviskiĭ
February 1979,
Mutation research,
E S Preobrazhenskaia, and
L M Klebanova, and
E I Budovskiĭ, and
A S Kriviskiĭ
June 1977,
Biokhimiia (Moscow, Russia),
E S Preobrazhenskaia, and
L M Klebanova, and
E I Budovskiĭ, and
A S Kriviskiĭ
January 1982,
Molekuliarnaia biologiia,
E S Preobrazhenskaia, and
L M Klebanova, and
E I Budovskiĭ, and
A S Kriviskiĭ
January 1975,
Voprosy virusologii,
E S Preobrazhenskaia, and
L M Klebanova, and
E I Budovskiĭ, and
A S Kriviskiĭ
May 1985,
Molekuliarnaia genetika, mikrobiologiia i virusologiia,
E S Preobrazhenskaia, and
L M Klebanova, and
E I Budovskiĭ, and
A S Kriviskiĭ
April 1965,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
E S Preobrazhenskaia, and
L M Klebanova, and
E I Budovskiĭ, and
A S Kriviskiĭ
February 1971,
Journal of molecular biology,
E S Preobrazhenskaia, and
L M Klebanova, and
E I Budovskiĭ, and
A S Kriviskiĭ
January 1975,
Archives of virology,
E S Preobrazhenskaia, and
L M Klebanova, and
E I Budovskiĭ, and
A S Kriviskiĭ
August 1976,
Biokhimiia (Moscow, Russia),
