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Five infants with congenital immune defects are presented. Three had various combined immune deficiencies (CID) and two had thymic deficiencies only. As bone marrow or thymus transplantations were not feasible in these patients, we attempted treatment with thymic humoral factor (THF), a thymic hormone, by daily i.m. injections during biweekly courses. In one CID patient, a partial improvement in immune indices and temporary clinical improvement were achieved. In the other two, THF did not arrest the patients' demise. The two patients with thymic dysplasia benefitted repeatedly from THF treatment, as exemplified by the disappearance of wasting, diarrhea and infections and by reconstitution of T cell parameters. Nevertheless, the patients relapsed after prolonged periods without THF administration. We therefore propose the administration of long-term, continuous or intermittent thymic hormone replacement therapy in infants with congenital thymic defects. Early diagnosis and immediate institution of treatment will probably improve prognosis.
Z T Handzel, and
Y Elitsur, and
S Algrimawi, and
S Moses, and
A Keynan, and
I Amitai, and
M Pecht, and
Y Burstein, and
V Buchner, and
N Trainin
November 1984,
Cancer,
Z T Handzel, and
Y Elitsur, and
S Algrimawi, and
S Moses, and
A Keynan, and
I Amitai, and
M Pecht, and
Y Burstein, and
V Buchner, and
N Trainin
January 1990,
Natural immunity and cell growth regulation,
Z T Handzel, and
Y Elitsur, and
S Algrimawi, and
S Moses, and
A Keynan, and
I Amitai, and
M Pecht, and
Y Burstein, and
V Buchner, and
N Trainin
January 1986,
Archives francaises de pediatrie,
Z T Handzel, and
Y Elitsur, and
S Algrimawi, and
S Moses, and
A Keynan, and
I Amitai, and
M Pecht, and
Y Burstein, and
V Buchner, and
N Trainin
November 2021,
Immunology and allergy clinics of North America,
Z T Handzel, and
Y Elitsur, and
S Algrimawi, and
S Moses, and
A Keynan, and
I Amitai, and
M Pecht, and
Y Burstein, and
V Buchner, and
N Trainin
October 2019,
Pediatric clinics of North America,
Z T Handzel, and
Y Elitsur, and
S Algrimawi, and
S Moses, and
A Keynan, and
I Amitai, and
M Pecht, and
Y Burstein, and
V Buchner, and
N Trainin
January 2020,
Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993),
Z T Handzel, and
Y Elitsur, and
S Algrimawi, and
S Moses, and
A Keynan, and
I Amitai, and
M Pecht, and
Y Burstein, and
V Buchner, and
N Trainin
January 1985,
Nihon Kyobu Shikkan Gakkai zasshi,
Z T Handzel, and
Y Elitsur, and
S Algrimawi, and
S Moses, and
A Keynan, and
I Amitai, and
M Pecht, and
Y Burstein, and
V Buchner, and
N Trainin
December 1984,
Israel journal of medical sciences,
Z T Handzel, and
Y Elitsur, and
S Algrimawi, and
S Moses, and
A Keynan, and
I Amitai, and
M Pecht, and
Y Burstein, and
V Buchner, and
N Trainin
June 1981,
Pediatrie,
Z T Handzel, and
Y Elitsur, and
S Algrimawi, and
S Moses, and
A Keynan, and
I Amitai, and
M Pecht, and
Y Burstein, and
V Buchner, and
N Trainin
January 1984,
Annales d'endocrinologie,
