-transparent.png){kind=logo}
The localization of secretory immunoglobulin A (IgA) in Paneth cells was immunohistochemically studied in germ-free (Gf) and ex-Gf rats that had been injected with feces obtained from specific-pathogen-free (SPF) rats. In Gf as well as SPF rats, the secretory granules of Paneth cells and the brush borders of crypt cells exhibited IgA immunoreactivity. At 12 and 24 h after inoculation, it was found that, concomitant with the occurrence of considerable degranulation, the IgA immunoreactivity in Paneth cells disappeared, except of the margin of supranuclear vacuoles. In contrast, the IgA immunoreactivity of the crypt-cell brush borders was unchanged. Four days after inoculation, secretory granules exhibiting IgA immunoreactivity reaccumulated in Paneth cells. The present study suggests that Paneth cells regulate the bacterial milieu in the intestine by releasing secretory granules containing IgA into the crypt lumen.
Y Satoh, and
K Ishikawa, and
H Tanaka, and
K Ono
August 1984,
Archivum histologicum Japonicum = Nihon soshikigaku kiroku,
Y Satoh, and
K Ishikawa, and
H Tanaka, and
K Ono
August 1988,
Cell and tissue research,
Y Satoh, and
K Ishikawa, and
H Tanaka, and
K Ono
May 1970,
Laboratory investigation; a journal of technical methods and pathology,
Y Satoh, and
K Ishikawa, and
H Tanaka, and
K Ono
March 1978,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
Y Satoh, and
K Ishikawa, and
H Tanaka, and
K Ono
October 1955,
The Journal of nutrition,
Y Satoh, and
K Ishikawa, and
H Tanaka, and
K Ono
July 1969,
Journal of anatomy,
Y Satoh, and
K Ishikawa, and
H Tanaka, and
K Ono
November 1974,
Acta pathologica et microbiologica Scandinavica. Section A, Pathology,
Y Satoh, and
K Ishikawa, and
H Tanaka, and
K Ono
January 1988,
Cell and tissue research,
Y Satoh, and
K Ishikawa, and
H Tanaka, and
K Ono
July 2006,
The American journal of gastroenterology,
Y Satoh, and
K Ishikawa, and
H Tanaka, and
K Ono
January 1986,
Anatomy and embryology,
