Role of Histone Post-Translational Modifications in Inflammatory Diseases. 2022

Yingying Lin, and Ting Qiu, and Guifeng Wei, and Yueyue Que, and Wenxin Wang, and Yichao Kong, and Tian Xie, and Xiabin Chen
School of Pharmacy, Hangzhou Normal University, Hangzhou, China.

Inflammation is a defensive reaction for external stimuli to the human body and generally accompanied by immune responses, which is associated with multiple diseases such as atherosclerosis, type 2 diabetes, Alzheimer's disease, psoriasis, asthma, chronic lung diseases, inflammatory bowel disease, and multiple virus-associated diseases. Epigenetic mechanisms have been demonstrated to play a key role in the regulation of inflammation. Common epigenetic regulations are DNA methylation, histone modifications, and non-coding RNA expression; among these, histone modifications embrace various post-modifications including acetylation, methylation, phosphorylation, ubiquitination, and ADP ribosylation. This review focuses on the significant role of histone modifications in the progression of inflammatory diseases, providing the potential target for clinical therapy of inflammation-associated diseases.

UI MeSH Term Description Entries
D007249 Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D011499 Protein Processing, Post-Translational Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility. Amino Acid Modification, Post-Translational,Post-Translational Modification,Post-Translational Protein Modification,Posttranslational Modification,Protein Modification, Post-Translational,Amino Acid Modification, Posttranslational,Post-Translational Amino Acid Modification,Post-Translational Modifications,Post-Translational Protein Processing,Posttranslational Amino Acid Modification,Posttranslational Modifications,Posttranslational Protein Processing,Protein Processing, Post Translational,Protein Processing, Posttranslational,Amino Acid Modification, Post Translational,Modification, Post-Translational,Modification, Post-Translational Protein,Modification, Posttranslational,Modifications, Post-Translational,Modifications, Post-Translational Protein,Modifications, Posttranslational,Post Translational Amino Acid Modification,Post Translational Modification,Post Translational Modifications,Post Translational Protein Modification,Post Translational Protein Processing,Post-Translational Protein Modifications,Processing, Post-Translational Protein,Processing, Posttranslational Protein,Protein Modification, Post Translational,Protein Modifications, Post-Translational
D003924 Diabetes Mellitus, Type 2 A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY. Diabetes Mellitus, Adult-Onset,Diabetes Mellitus, Ketosis-Resistant,Diabetes Mellitus, Maturity-Onset,Diabetes Mellitus, Non-Insulin-Dependent,Diabetes Mellitus, Slow-Onset,Diabetes Mellitus, Stable,MODY,Maturity-Onset Diabetes Mellitus,NIDDM,Diabetes Mellitus, Non Insulin Dependent,Diabetes Mellitus, Noninsulin Dependent,Diabetes Mellitus, Noninsulin-Dependent,Diabetes Mellitus, Type II,Maturity-Onset Diabetes,Noninsulin-Dependent Diabetes Mellitus,Type 2 Diabetes,Type 2 Diabetes Mellitus,Adult-Onset Diabetes Mellitus,Diabetes Mellitus, Adult Onset,Diabetes Mellitus, Ketosis Resistant,Diabetes Mellitus, Maturity Onset,Diabetes Mellitus, Slow Onset,Diabetes, Maturity-Onset,Diabetes, Type 2,Ketosis-Resistant Diabetes Mellitus,Maturity Onset Diabetes,Maturity Onset Diabetes Mellitus,Non-Insulin-Dependent Diabetes Mellitus,Noninsulin Dependent Diabetes Mellitus,Slow-Onset Diabetes Mellitus,Stable Diabetes Mellitus
D006657 Histones Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each. Histone,Histone H1,Histone H1(s),Histone H2a,Histone H2b,Histone H3,Histone H3.3,Histone H4,Histone H5,Histone H7
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D019175 DNA Methylation Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor. DNA Methylations,Methylation, DNA,Methylations, DNA

Related Publications

Yingying Lin, and Ting Qiu, and Guifeng Wei, and Yueyue Que, and Wenxin Wang, and Yichao Kong, and Tian Xie, and Xiabin Chen
January 2013, Current pharmaceutical design,
Yingying Lin, and Ting Qiu, and Guifeng Wei, and Yueyue Que, and Wenxin Wang, and Yichao Kong, and Tian Xie, and Xiabin Chen
August 2019, Biochimica et biophysica acta. Molecular basis of disease,
Yingying Lin, and Ting Qiu, and Guifeng Wei, and Yueyue Que, and Wenxin Wang, and Yichao Kong, and Tian Xie, and Xiabin Chen
January 2013, Current pharmaceutical design,
Yingying Lin, and Ting Qiu, and Guifeng Wei, and Yueyue Que, and Wenxin Wang, and Yichao Kong, and Tian Xie, and Xiabin Chen
February 2021, The Biochemical journal,
Yingying Lin, and Ting Qiu, and Guifeng Wei, and Yueyue Que, and Wenxin Wang, and Yichao Kong, and Tian Xie, and Xiabin Chen
March 2024, Epigenomics,
Yingying Lin, and Ting Qiu, and Guifeng Wei, and Yueyue Que, and Wenxin Wang, and Yichao Kong, and Tian Xie, and Xiabin Chen
February 2023, Seminars in cell & developmental biology,
Yingying Lin, and Ting Qiu, and Guifeng Wei, and Yueyue Que, and Wenxin Wang, and Yichao Kong, and Tian Xie, and Xiabin Chen
January 2022, Frontiers in oncology,
Yingying Lin, and Ting Qiu, and Guifeng Wei, and Yueyue Que, and Wenxin Wang, and Yichao Kong, and Tian Xie, and Xiabin Chen
January 2015, ACS chemical biology,
Yingying Lin, and Ting Qiu, and Guifeng Wei, and Yueyue Que, and Wenxin Wang, and Yichao Kong, and Tian Xie, and Xiabin Chen
April 2017, Cryobiology,
Yingying Lin, and Ting Qiu, and Guifeng Wei, and Yueyue Que, and Wenxin Wang, and Yichao Kong, and Tian Xie, and Xiabin Chen
April 2024, Biology of reproduction,
Copied contents to your clipboard!