To determine the fracture load before and after artificial aging of implant-supported 4-unit cantilever fixed dental prostheses (FDP) with frameworks made of two differently filled polyetheretherketone (PEEK) compounds and veneered using three different techniques. A total of 120 duplicate 4-unit FDP frameworks were produced (n = 60 milled from PEEK, 20% TiO2 filled and n = 60 pressed from PEEK, 30% TiO2 filled) and veneered using three different techniques: (i) digital veneerings, (ii) conventional resin composite veneerings and (iii) prefabricated veneers (n = 20 per subgroup). The FDPs were adhesively bonded to titanium abutments and the fracture load was measured in a universal testing machine (1 mm/min) before and after artificial aging in a mastication simulator (1,200,000 cycles, 50 N, TC: 5/55 °C, 6000 cycles). The fracture patterns were analyzed using digital microscopy. Data were analyzed using the Kolmogorov-Smirnov test, two-way ANOVA, post hoc Scheffé, Chi2-test (p < 0.05), and Weibull modulus m, as well as fracture patterns using the Ciba-Geigy table. Veneering technique and filler content significantly affected the fracture load (p < 0.001). Prefabricated veneers showed higher fracture load (p ≤ 0.001) whereas digital and conventional veneerings were similar (p = 0.451). PEEK with 30% filler content presented higher fracture load (p < 0.001) compared with PEEK with 20%. Aging showed no effect on fracture load (p = 0.176). Regarding fracture types, no significant differences were found among the groups (p = 0.055). Filler content of PEEK compound as well as veneering technique influenced fracture load while aging had no effect on fracture load. FDPs made of PEEK with 30% of filler content veneered using prefabricated veneers had the highest fracture resistance.