BIOMAT Database Logo BIOMAT Database Logo

[Prevalence of viral hepatitis B markers among blood donors in the Republic of Guinea]. 2022

S Boumbaly, and T A L Balde, and A V Semenov, and Yu V Ostankova, and E N Serikova, and E V Naidenova, and D E Valutite, and A N Shchemelev, and E B Zueva, and E V Esaulenko, and Areg A Totolian
International Tropical Infections Research Center; Research Institute of Applied Biology of Guinea.

The problem of transfusion safety in relation to parenteral viral hepatitis still remains relevant. Viral hepatitis B (HB) remains the most common viral infection transmitted through transfusion procedures. One of the natural phases of chronic hepatitis B (CHB) is occult hepatitis B infection (OBI), characterized by an undetectable HBsAg (regardless of the other serological markers content) in the presence of hepatitis B virus (HBV) DNA in the liver tissue and an extremely low, up to undetectable, level of viral load in the blood. In the Republic of Guinea, as in most countries on the continent, the prevention of HBV transmission through transfusion is still based on HBsAg serological testing of donors only. In this connection, OBI remains as a potential threat to blood transfusion safety. Detection of HBV DNA is a reliable preventive measure against transmission of the virus from donors with HBsAg-negative HBV infection, especially in highly endemic regions. In this regard, the study was conducted to substantiate recommendations for improving blood safety against the background of significant HBV prevalence in the Republic of Guinea.The aim of the work was the evaluation of serological and molecular markers of HBV infection in blood donors in the Republic of Guinea. We examined 250 blood samples obtained from donors living in Conakry, Republic of Guinea. Samples were tested for the presence of serological (surface antigen, HBsAg; antibodies (ABs) to surface (anti-HBs IgG) and core (anti-HBc IgG) antigens) and molecular (DNA) markers of HBV infection. The overall detection rate of hepatitis B markers was 83.2%; HBsAg was detected in 16.4% of all individuals. The high incidence of HBsAg in men (19.55%) compared to women (8.45%) was shown, the relative risk of HBV infection with the formation of HBsAg-positive chronic hepatitis B in males was also significantly higher. The prevalence of the HBV DNA in the study group was 30.4%, the OBI cases accounted for 15.6%. The prevalence of this form of the disease was shown in donors aged 30-49 years (24.78%), in the group of people younger than 30 years, the incidence was lower (8.73%), and at the age of over 50 years, OBI was not detected. Based on the phylogenetic analysis of 76 virus isolates, it was shown that genotype E prevails in the examined group (85.53%).Cases of pathogen DNA detection occurred in HBsAg-negative blood donors in the presence of anti-HBs IgG (n = 4), as well as in the simultaneous presence of ABs anti-HBs IgG and anti-HBc IgG (n = 7). The viral load exceeded 200 IU/ml in OBI samples. Escape mutations were detected by sequencing in each OBI sample, contributing to the virus escaping from diagnostic based on screening for HBsAg. Assessment of the prevalence viral hepatitis B markers in blood donors, determination of genotypes and clinically significant mutations of virus variants are necessary to ensure safe medical manipulations, control and prevention of the spread of this infectious agent.

UI MeSH Term Description Entries
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D008297 Male Males
D010802 Phylogeny The relationships of groups of organisms as reflected by their genetic makeup. Community Phylogenetics,Molecular Phylogenetics,Phylogenetic Analyses,Phylogenetic Analysis,Phylogenetic Clustering,Phylogenetic Comparative Analysis,Phylogenetic Comparative Methods,Phylogenetic Distance,Phylogenetic Generalized Least Squares,Phylogenetic Groups,Phylogenetic Incongruence,Phylogenetic Inference,Phylogenetic Networks,Phylogenetic Reconstruction,Phylogenetic Relatedness,Phylogenetic Relationships,Phylogenetic Signal,Phylogenetic Structure,Phylogenetic Tree,Phylogenetic Trees,Phylogenomics,Analyse, Phylogenetic,Analysis, Phylogenetic,Analysis, Phylogenetic Comparative,Clustering, Phylogenetic,Community Phylogenetic,Comparative Analysis, Phylogenetic,Comparative Method, Phylogenetic,Distance, Phylogenetic,Group, Phylogenetic,Incongruence, Phylogenetic,Inference, Phylogenetic,Method, Phylogenetic Comparative,Molecular Phylogenetic,Network, Phylogenetic,Phylogenetic Analyse,Phylogenetic Clusterings,Phylogenetic Comparative Analyses,Phylogenetic Comparative Method,Phylogenetic Distances,Phylogenetic Group,Phylogenetic Incongruences,Phylogenetic Inferences,Phylogenetic Network,Phylogenetic Reconstructions,Phylogenetic Relatednesses,Phylogenetic Relationship,Phylogenetic Signals,Phylogenetic Structures,Phylogenetic, Community,Phylogenetic, Molecular,Phylogenies,Phylogenomic,Reconstruction, Phylogenetic,Relatedness, Phylogenetic,Relationship, Phylogenetic,Signal, Phylogenetic,Structure, Phylogenetic,Tree, Phylogenetic
D001782 Blood Donors Individuals supplying blood or blood components for transfer to histocompatible recipients. Blood Donor,Donor, Blood,Donors, Blood
D004279 DNA, Viral Deoxyribonucleic acid that makes up the genetic material of viruses. Viral DNA
D005260 Female Females
D006509 Hepatitis B INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact. Hepatitis B Virus Infection
D006512 Hepatitis B Core Antigens The hepatitis B antigen within the core of the Dane particle, the infectious hepatitis virion. HBcAg,Hepatitis B Core Antigen
D006514 Hepatitis B Surface Antigens Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen. Australia Antigen,HBsAg,Hepatitis B Surface Antigen,Antigen, Australia
D006515 Hepatitis B virus The type species of the genus ORTHOHEPADNAVIRUS which causes human HEPATITIS B and is also apparently a causal agent in human HEPATOCELLULAR CARCINOMA. The Dane particle is an intact hepatitis virion, named after its discoverer. Non-infectious spherical and tubular particles are also seen in the serum. Dane Particle,Hepatitis Virus, Homologous Serum,B virus, Hepatitis,Hepatitis B viruses,Particle, Dane,viruses, Hepatitis B

Related Publications

S Boumbaly, and T A L Balde, and A V Semenov, and Yu V Ostankova, and E N Serikova, and E V Naidenova, and D E Valutite, and A N Shchemelev, and E B Zueva, and E V Esaulenko, and Areg A Totolian
[Prevalence of hepatitis B viral markers in Vietnamese blood donors].
June 1985, Revue francaise de transfusion et immuno-hematologie,
S Boumbaly, and T A L Balde, and A V Semenov, and Yu V Ostankova, and E N Serikova, and E V Naidenova, and D E Valutite, and A N Shchemelev, and E B Zueva, and E V Esaulenko, and Areg A Totolian
Prevalence of viral markers among blood donors in Tunisia.
January 2001, Clinical laboratory,
S Boumbaly, and T A L Balde, and A V Semenov, and Yu V Ostankova, and E N Serikova, and E V Naidenova, and D E Valutite, and A N Shchemelev, and E B Zueva, and E V Esaulenko, and Areg A Totolian
Viral hepatitis markers in Thai blood donors.
January 1984, Vox sanguinis,
S Boumbaly, and T A L Balde, and A V Semenov, and Yu V Ostankova, and E N Serikova, and E V Naidenova, and D E Valutite, and A N Shchemelev, and E B Zueva, and E V Esaulenko, and Areg A Totolian
Prevalence of hepatitis B virus markers among Ethiopian blood donors: is HBsAg screening necessary?
October 1987, Tropical and geographical medicine,
S Boumbaly, and T A L Balde, and A V Semenov, and Yu V Ostankova, and E N Serikova, and E V Naidenova, and D E Valutite, and A N Shchemelev, and E B Zueva, and E V Esaulenko, and Areg A Totolian
Prevalence of viral markers among first-time Arab blood donors in Kuwait.
December 2005, Transfusion,
S Boumbaly, and T A L Balde, and A V Semenov, and Yu V Ostankova, and E N Serikova, and E V Naidenova, and D E Valutite, and A N Shchemelev, and E B Zueva, and E V Esaulenko, and Areg A Totolian
[Markers of hepatitis B virus in blood donors].
November 1985, Gematologiia i transfuziologiia,
S Boumbaly, and T A L Balde, and A V Semenov, and Yu V Ostankova, and E N Serikova, and E V Naidenova, and D E Valutite, and A N Shchemelev, and E B Zueva, and E V Esaulenko, and Areg A Totolian
The current incidence, prevalence, and residual risk of hepatitis B viral infections among voluntary blood donors in China.
December 2017, BMC infectious diseases,
S Boumbaly, and T A L Balde, and A V Semenov, and Yu V Ostankova, and E N Serikova, and E V Naidenova, and D E Valutite, and A N Shchemelev, and E B Zueva, and E V Esaulenko, and Areg A Totolian
[Prevalence of viral markers for hepatitis B, C and human immunodeficiency virus in volunteer blood donors in Northeast Mexico].
January 1997, Revista de gastroenterologia de Mexico,
S Boumbaly, and T A L Balde, and A V Semenov, and Yu V Ostankova, and E N Serikova, and E V Naidenova, and D E Valutite, and A N Shchemelev, and E B Zueva, and E V Esaulenko, and Areg A Totolian
Hepatitis B viral DNA among HBs antigen negative healthy blood donors.
March 2013, Hepatitis monthly,
S Boumbaly, and T A L Balde, and A V Semenov, and Yu V Ostankova, and E N Serikova, and E V Naidenova, and D E Valutite, and A N Shchemelev, and E B Zueva, and E V Esaulenko, and Areg A Totolian
[Markers of viral hepatitis in blood donors. Study apropos of 300 donors].
October 1999, La Tunisie medicale,
Copied contents to your clipboard!