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Bone marrow cells produce soluble mediators with structural and functional heterogeneity. They were found to stimulate antibody production at the peak of the immune response, owing to compounds of a peptide nature (Mr 2000-1300). Active material was isolated by means of gel chromatography and electrophoresis. This material positively reacts with ninhydrin, and has maximum absorption close to 278 nm. Its antibody-stimulating activity decreased or stopped completely after treatment with proteolytic enzymes. Apart from the immunostimulating activity, bone marrow mediators have opiate-like activity. They have an analgetic effect, and interact with the opiate receptors of brain nerve cells. After a physicochemical and functional analysis, we conclude that bone marrow produces regulatory peptides that were previously unknown. We called them myelopeptides.
R V Petrov, and
A A Mikhailova, and
L A Zakharova, and
A M Vasilenko, and
A V Katlinsky
January 1985,
Vestnik Akademii meditsinskikh nauk SSSR,
R V Petrov, and
A A Mikhailova, and
L A Zakharova, and
A M Vasilenko, and
A V Katlinsky
January 1986,
Doklady Akademii nauk SSSR,
R V Petrov, and
A A Mikhailova, and
L A Zakharova, and
A M Vasilenko, and
A V Katlinsky
February 1984,
Gematologiia i transfuziologiia,
R V Petrov, and
A A Mikhailova, and
L A Zakharova, and
A M Vasilenko, and
A V Katlinsky
December 2009,
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova,
R V Petrov, and
A A Mikhailova, and
L A Zakharova, and
A M Vasilenko, and
A V Katlinsky
January 1989,
Doklady Akademii nauk SSSR,
R V Petrov, and
A A Mikhailova, and
L A Zakharova, and
A M Vasilenko, and
A V Katlinsky
January 1982,
Doklady Akademii nauk SSSR,
R V Petrov, and
A A Mikhailova, and
L A Zakharova, and
A M Vasilenko, and
A V Katlinsky
January 2010,
Bioorganicheskaia khimiia,
R V Petrov, and
A A Mikhailova, and
L A Zakharova, and
A M Vasilenko, and
A V Katlinsky
January 2022,
Advances in experimental medicine and biology,
R V Petrov, and
A A Mikhailova, and
L A Zakharova, and
A M Vasilenko, and
A V Katlinsky
January 1999,
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery,
R V Petrov, and
A A Mikhailova, and
L A Zakharova, and
A M Vasilenko, and
A V Katlinsky
December 1984,
Biulleten' eksperimental'noi biologii i meditsiny,
