BIOMAT Database Logo BIOMAT Database Logo

Recent progress in the synthesis of pyrrolo[2,1-a]isoquinolines. 2022

Hai-Lei Cui
Laboratory of Asymmetric Synthesis, Chongqing University of Arts and Sciences, 319 Honghe Ave., Yongchuan, Chongqing, 402160, PR China. cuihailei616@163.com.

Pyrrolo[2,1-a]isoquinolines occur frequently in a large number of bioactive natural products and pharmaceutically important molecules. The synthesis of pyrrolo[2,1-a]isoquinoline derivatives is an easy and useful way to produce artificial molecules with potential applications. A huge number of excellent methodologies for constructing pyrrolo[2,1-a]isoquinolines have been reported in the last decade. This review summarizes the recent advances in this research field covering from 2011 to 2021.

UI MeSH Term Description Entries
D007546 Isoquinolines A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids such as papaverine. (From Stedman, 25th ed)

Related Publications

Hai-Lei Cui
Synthesis and pharmacological evaluation of some pyrrolo[2,1-a]isoquinolines.
July 1968, Journal of medicinal chemistry,
Hai-Lei Cui
Synthesis of pyrrolo[2,1-a]isoquinolines by multicomponent 1,3-dipolar cycloaddition.
February 2013, Molecules (Basel, Switzerland),
Hai-Lei Cui
A copper-catalyzed tandem synthesis of indolo- and pyrrolo[2,1-a]isoquinolines.
January 2009, Angewandte Chemie (International ed. in English),
Hai-Lei Cui
NHC-Mediated Synthesis of Pyrrolo[2,1-a]isoquinolines and Their Photophysical Investigations.
March 2017, Chemistry, an Asian journal,
Hai-Lei Cui
Copper-Catalyzed Synthesis of Pyrrolo[1,2-c]quinazolines and Pyrrolo[2,1-a]isoquinolines and Antiplasmodial Evaluation.
July 2023, The Journal of organic chemistry,
Hai-Lei Cui
Copper-catalyzed tandem synthesis of indolo-, pyrrolo[2,1-a]isoquinolines, naphthyridines and bisindolo/pyrrolo[2,1-a]isoquinolines via hydroamination of ortho-haloarylalkynes followed by C-2 arylation.
September 2012, The Journal of organic chemistry,
Hai-Lei Cui
Synthesis and antileukemic activity of bis[[(carbamoyl)oxy]methyl]- substituted pyrrolo[2,1-a]isoquinolines, pyrrolo[1,2-a]quinolines, pyrrolo[2,1-a]isobenzazepines, and pyrrolo[1,2-a]benzazepines.
November 1988, Journal of medicinal chemistry,
Hai-Lei Cui
Diethyl Azodicarboxylate-Promoted Oxidative [3 + 2] Cycloaddition for the Synthesis of Pyrrolo[2,1-a]isoquinolines.
January 2021, The Journal of organic chemistry,
Hai-Lei Cui
Controllable Diastereodivergent Synthesis of Pyrrolo[2,1-a]isoquinolines via Catalytic Intramolecular Acylsulfenylation of Activated Alkenes.
May 2017, The Journal of organic chemistry,
Hai-Lei Cui
Diastereoselective intramolecular alpha-amidoalkylation reactions of L-DOPA derivatives. Asymmetric synthesis of pyrrolo[2,1-a]isoquinolines.
December 2005, The Journal of organic chemistry,
Copied contents to your clipboard!