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Low-dose interferon-alpha (IFN-alpha) therapy is consistently effective in the treatment of hairy cell leukemia (HCL). In two cases of resistance to IFN-alpha administration, we diagnosed variant HCL, a form of HCL with intermediate features between typical HCL and B cell prolymphocytic leukemia. We tried to distinguish variant and typical hairy cells (HCs) by Northern blot analysis of the oncogenes expressed in vivo. We report that variant HCs contain c-myc transcripts in contrast to typical HCs, whereas c-fos transcripts are detected in both cell types. We also report that the mRNA levels of c-myc are not modified in variant HCs by IFN-alpha treatment, whereas the level of c-fos mRNA is modulated in both types of HCs. Our findings suggest that the failure to modulate c-myc expression in vivo might indicate the limits of low-dose IFN-alpha therapy.
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P Loiseau, and
S Castaigne, and
L Degos, and
G Flandrin, and
F Dautry
June 1999,
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P Lehn, and
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F Dautry
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August 1988,
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September 1991,
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P Lehn, and
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February 1991,
Blood,
P Lehn, and
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F Dautry
November 1988,
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P Lehn, and
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F Dautry
February 1990,
Blood,
P Lehn, and
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S Castaigne, and
L Degos, and
G Flandrin, and
F Dautry
April 1985,
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P Lehn, and
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F Dautry
June 1992,
Tumori,
