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Twelve infants and children were treated with sublingual application of the calcium antagonist nifedipine. Blood pressure fell within 1 h following administration of nifedipine to age-related normal values. Whereas plasma renin activity, plasma concentrations of aldosterone and arginine vasopressin did not change within 1 h after drug application, plasma noradrenaline rose (p less than 0.05), probably in response to vasodilatation. Plasma concentration of nifedipine at 30 and 60 min after application correlated positively with the fall in mean arterial pressure. Nifedipine was well tolerated and appeared to be an effective and safe drug in the treatment of acute rises of blood pressure in infants and children.
W Rascher, and
K E Bonzel, and
H Ruder, and
D E Müller-Wiefel, and
K Schärer
April 1989,
Archives of disease in childhood,
W Rascher, and
K E Bonzel, and
H Ruder, and
D E Müller-Wiefel, and
K Schärer
August 1988,
Archives of disease in childhood,
W Rascher, and
K E Bonzel, and
H Ruder, and
D E Müller-Wiefel, and
K Schärer
January 1983,
Harefuah,
W Rascher, and
K E Bonzel, and
H Ruder, and
D E Müller-Wiefel, and
K Schärer
June 1987,
The Journal of the Association of Physicians of India,
W Rascher, and
K E Bonzel, and
H Ruder, and
D E Müller-Wiefel, and
K Schärer
March 1983,
Israel journal of medical sciences,
W Rascher, and
K E Bonzel, and
H Ruder, and
D E Müller-Wiefel, and
K Schärer
January 1983,
Indian heart journal,
W Rascher, and
K E Bonzel, and
H Ruder, and
D E Müller-Wiefel, and
K Schärer
March 1982,
Circulation,
W Rascher, and
K E Bonzel, and
H Ruder, and
D E Müller-Wiefel, and
K Schärer
May 1981,
Chest,
W Rascher, and
K E Bonzel, and
H Ruder, and
D E Müller-Wiefel, and
K Schärer
January 1985,
Hypertension (Dallas, Tex. : 1979),
W Rascher, and
K E Bonzel, and
H Ruder, and
D E Müller-Wiefel, and
K Schärer
August 1986,
The Journal of the Association of Physicians of India,
