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The distribution of 125I-insulin in cardiocytes was analyzed by light microscope autoradiography. Semithin sections were used to distinguish between surface-bound and internalized tracer. At 37 degrees C, when steady state binding conditions were reached, 40 to 60% of the cell-bound tracer was located in the plasma membrane region and the remainder was in the cell interior. Autoradiograms of whole cells were used to study the distribution of tracer molecules on the cell surface. Because Poisson distributions of silver grains were observed on 90% of the cells, it was concluded that the distribution of the insulin-receptor complexes was close to random. In contrast to the findings of Schlessinger et al., no aggregation of insulin-receptor complexes into patches was observed.
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