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Acute infusion of pharmacological doses of angiotensin II stimulates the release of prostaglandin I2 (PGI2), which may modulate the vasoconstrictor response. It is uncertain whether sustained small increases in the plasma concentration of angiotensin II has the same effect. To investigate this further, low doses of angiotensin II were infused into conscious sodium replete dogs for 3 h. PGI2 synthesis was assessed by measurement of a major metabolite of PGI2, 2,3-dinor-6-keto PGF1 alpha, in urine and plasma, using gas chromatography mass spectrometry. Angiotensin II infusion (15 ng/min per kg body weight) resulted in a 3-fold increase in plasma angiotensin II (50.8 +/- 5.4 to 149 +/- 11.2 pg/ml, P less than 0.01). Mean blood pressure increased (84.8 +/- 4.3 to 108 +/- 4.7 mm Hg, P less than 0.02) and renal blood flow decreased (201 +/- 46 to 127 +/- 13 ml/min, P less than 0.01) throughout the infusion. However there was no change in either the plasma concentration (11.3 +/- 2.5 to 9.1 +/- 1.0 pg/ml) or rate of urinary excretion of dinor-6-keto PGF1 alpha (1.75 +/- 0.28 to 1.85 +/- 0.41 ng/30 min) during the angiotensin II infusion. The results suggest that small sustained elevations of the plasma concentration of angiotensin II such as are likely to occur in conscious animals, do not persistently stimulate release of PGI2 in the systemic circulation.
M L Watson, and
R J Workman, and
W Herzer, and
R A Branch, and
J A Oates, and
A R Brash
November 1988,
Circulation research,
M L Watson, and
R J Workman, and
W Herzer, and
R A Branch, and
J A Oates, and
A R Brash
October 1977,
The American journal of physiology,
M L Watson, and
R J Workman, and
W Herzer, and
R A Branch, and
J A Oates, and
A R Brash
January 1984,
Hypertension (Dallas, Tex. : 1979),
M L Watson, and
R J Workman, and
W Herzer, and
R A Branch, and
J A Oates, and
A R Brash
November 1993,
Hypertension (Dallas, Tex. : 1979),
M L Watson, and
R J Workman, and
W Herzer, and
R A Branch, and
J A Oates, and
A R Brash
January 1986,
Basic research in cardiology,
M L Watson, and
R J Workman, and
W Herzer, and
R A Branch, and
J A Oates, and
A R Brash
March 1976,
The American journal of physiology,
M L Watson, and
R J Workman, and
W Herzer, and
R A Branch, and
J A Oates, and
A R Brash
January 1984,
Clinical and experimental hypertension. Part A, Theory and practice,
M L Watson, and
R J Workman, and
W Herzer, and
R A Branch, and
J A Oates, and
A R Brash
November 1986,
Clinical science (London, England : 1979),
M L Watson, and
R J Workman, and
W Herzer, and
R A Branch, and
J A Oates, and
A R Brash
November 1989,
The American journal of physiology,
M L Watson, and
R J Workman, and
W Herzer, and
R A Branch, and
J A Oates, and
A R Brash
July 1982,
American journal of veterinary research,
