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Six hundred and five patients with endoscopically diagnosed duodenal ulcer were randomly allocated to treatment with ranitidine 300 mg at night or ranitidine 150 mg twice daily in a prospective double-blind multicenter trial conducted in nine European countries. Endoscopy at 4 weeks showed complete ulcer healing in 246 of 301 patients (82%) treated with ranitidine 150 mg b.i.d. and 230 of 304 patients (76%) treated with ranitidine 300 mg at night. Cumulative healing rates at 8 weeks were 95 and 94% respectively. Both treatment regimens were equally effective at rapidly reducing the incidence of ulcer-related symptoms. Adverse events were few and consistent with those reported in previous studies with ranitidine 150 mg twice daily. The results of this trial indicate that a single nighttime dose of ranitidine is an effective and safe alternative to the twice daily regimen in the acute treatment of duodenal ulcer.
B Simon, and
G Bianchi Porro, and
M Cremer, and
G Dobrilla, and
U Haglund, and
S L Dunn, and
K Summers
April 1988,
The Journal of the Association of Physicians of India,
B Simon, and
G Bianchi Porro, and
M Cremer, and
G Dobrilla, and
U Haglund, and
S L Dunn, and
K Summers
September 1985,
The American journal of gastroenterology,
B Simon, and
G Bianchi Porro, and
M Cremer, and
G Dobrilla, and
U Haglund, and
S L Dunn, and
K Summers
September 1986,
Gut,
B Simon, and
G Bianchi Porro, and
M Cremer, and
G Dobrilla, and
U Haglund, and
S L Dunn, and
K Summers
August 1984,
Lancet (London, England),
B Simon, and
G Bianchi Porro, and
M Cremer, and
G Dobrilla, and
U Haglund, and
S L Dunn, and
K Summers
September 1986,
Scandinavian journal of gastroenterology,
B Simon, and
G Bianchi Porro, and
M Cremer, and
G Dobrilla, and
U Haglund, and
S L Dunn, and
K Summers
July 1989,
Fortschritte der Medizin,
B Simon, and
G Bianchi Porro, and
M Cremer, and
G Dobrilla, and
U Haglund, and
S L Dunn, and
K Summers
January 1993,
Acta gastroenterologica Latinoamericana,
B Simon, and
G Bianchi Porro, and
M Cremer, and
G Dobrilla, and
U Haglund, and
S L Dunn, and
K Summers
January 1989,
Revista do Hospital das Clinicas,
B Simon, and
G Bianchi Porro, and
M Cremer, and
G Dobrilla, and
U Haglund, and
S L Dunn, and
K Summers
July 1986,
International journal of clinical pharmacology, therapy, and toxicology,
B Simon, and
G Bianchi Porro, and
M Cremer, and
G Dobrilla, and
U Haglund, and
S L Dunn, and
K Summers
April 1989,
Alimentary pharmacology & therapeutics,
