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10 "false negative" chemical carcinogens, i.e. ineffective in bacterial mutagenicity assays, were thoroughly investigated for their genotoxic activity in the mould Aspergillus nidulans. Forward mutations (methionine suppressors), mitotic crossing-over and chromosome malsegregation were the end-points scored. Positive results were obtained in tests for the induction of mitotic segregation with benzene, ethylenethiourea and urethane, which increased the frequency of abnormal presumptive aneuploid colonies with euploid sectors showing whole chromosome segregation (i.e. non-disjunctional diploids and haploids). The same compounds were ineffective in increasing the frequency of mitotic crossing-over or forward mutations. The other chemical carcinogens investigated, namely acetamide, amitrole, dieldrin, heptachlor epoxide, nitrilotriacetic acid, p,p'-DDT and thiourea were ineffective both as inducers of forward mutations and mitotic segregation.
R Crebelli, and
D Bellincampi, and
G Conti, and
L Conti, and
G Morpurgo, and
A Carere
January 1989,
Annali dell'Istituto superiore di sanita,
R Crebelli, and
D Bellincampi, and
G Conti, and
L Conti, and
G Morpurgo, and
A Carere
March 1986,
Molecular & general genetics : MGG,
R Crebelli, and
D Bellincampi, and
G Conti, and
L Conti, and
G Morpurgo, and
A Carere
January 1986,
Mutation research,
R Crebelli, and
D Bellincampi, and
G Conti, and
L Conti, and
G Morpurgo, and
A Carere
September 1963,
Genetics,
R Crebelli, and
D Bellincampi, and
G Conti, and
L Conti, and
G Morpurgo, and
A Carere
December 1989,
Mutation research,
R Crebelli, and
D Bellincampi, and
G Conti, and
L Conti, and
G Morpurgo, and
A Carere
January 1962,
Acta microbiologica Polonica (1952),
R Crebelli, and
D Bellincampi, and
G Conti, and
L Conti, and
G Morpurgo, and
A Carere
January 1966,
Annali dell'Istituto superiore di sanita,
R Crebelli, and
D Bellincampi, and
G Conti, and
L Conti, and
G Morpurgo, and
A Carere
January 1969,
Mutation research,
R Crebelli, and
D Bellincampi, and
G Conti, and
L Conti, and
G Morpurgo, and
A Carere
February 1971,
Genetics,
R Crebelli, and
D Bellincampi, and
G Conti, and
L Conti, and
G Morpurgo, and
A Carere
April 1992,
Mutation research,
