BIOMAT Database Logo BIOMAT Database Logo

DNA antibodies detected by microhemagglutination test in the diagnosis of systemic lupus erythematosus. 1978

M Depiante-Depaoli, and C M Riera, and C Yantorno, and A Risemberg, and A Strussberg

A method of tanned erythrocyte agglutination of wide applicability is described for the study of DNA antibodies. The practical aspects of the method have been explored in estimation of antibodies to DNA in human cases of systemic lupus erythematosus, discoid lupus erythematosus, rheumatoid arthritis, other collagenoses and not related diseases. This method was found to be of high sensitivity and specificity, detecting DNA antibodies only in sera of systemic lupus erythematosus. Results were compared with those obtained by immunofluorescence test using rat liver hepatocytes as source of nuclei.

UI MeSH Term Description Entries
D008180 Lupus Erythematosus, Systemic A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Libman-Sacks Disease,Lupus Erythematosus Disseminatus,Systemic Lupus Erythematosus,Disease, Libman-Sacks,Libman Sacks Disease
D004247 DNA A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine). DNA, Double-Stranded,Deoxyribonucleic Acid,ds-DNA,DNA, Double Stranded,Double-Stranded DNA,ds DNA
D005455 Fluorescent Antibody Technique Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy. Antinuclear Antibody Test, Fluorescent,Coon's Technique,Fluorescent Antinuclear Antibody Test,Fluorescent Protein Tracing,Immunofluorescence Technique,Coon's Technic,Fluorescent Antibody Technic,Immunofluorescence,Immunofluorescence Technic,Antibody Technic, Fluorescent,Antibody Technics, Fluorescent,Antibody Technique, Fluorescent,Antibody Techniques, Fluorescent,Coon Technic,Coon Technique,Coons Technic,Coons Technique,Fluorescent Antibody Technics,Fluorescent Antibody Techniques,Fluorescent Protein Tracings,Immunofluorescence Technics,Immunofluorescence Techniques,Protein Tracing, Fluorescent,Protein Tracings, Fluorescent,Technic, Coon's,Technic, Fluorescent Antibody,Technic, Immunofluorescence,Technics, Fluorescent Antibody,Technics, Immunofluorescence,Technique, Coon's,Technique, Fluorescent Antibody,Technique, Immunofluorescence,Techniques, Fluorescent Antibody,Techniques, Immunofluorescence,Tracing, Fluorescent Protein,Tracings, Fluorescent Protein
D006386 Hemagglutination Tests Sensitive tests to measure certain antigens, antibodies, or viruses, using their ability to agglutinate certain erythrocytes. (From Stedman, 26th ed) Hemagglutination Test,Test, Hemagglutination,Tests, Hemagglutination
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000906 Antibodies Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
D001172 Arthritis, Rheumatoid A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated. Rheumatoid Arthritis

Related Publications

M Depiante-Depaoli, and C M Riera, and C Yantorno, and A Risemberg, and A Strussberg
Microhemagglutination test for the detection of nucleoprotein antibody in systemic lupus erythematosus.
July 1975, American journal of clinical pathology,
M Depiante-Depaoli, and C M Riera, and C Yantorno, and A Risemberg, and A Strussberg
DNA haemagglutination test in the diagnosis of systemic lupus erythematosus.
September 1965, Annals of the rheumatic diseases,
M Depiante-Depaoli, and C M Riera, and C Yantorno, and A Risemberg, and A Strussberg
Microhemagglutination test for detection of antibodies to nuclear Sm and ribonucleoprotein antigens in systemic lupus erythematosus and related diseases.
November 1978, American journal of clinical pathology,
M Depiante-Depaoli, and C M Riera, and C Yantorno, and A Risemberg, and A Strussberg
Anti-DNA antibodies in systemic lupus erythematosus.
May 1992, Rheumatic diseases clinics of North America,
M Depiante-Depaoli, and C M Riera, and C Yantorno, and A Risemberg, and A Strussberg
Circulating DNA-antibodies in systemic lupus erythematosus.
January 1982, Rheumatology international,
M Depiante-Depaoli, and C M Riera, and C Yantorno, and A Risemberg, and A Strussberg
Ribosomal antibodies detected by immunofluorescence in systemic lupus erythematosus and other collagenoses.
August 1974, Clinical and experimental immunology,
M Depiante-Depaoli, and C M Riera, and C Yantorno, and A Risemberg, and A Strussberg
Antinuclear antibodies in the diagnosis of systemic lupus erythematosus.
February 1979, JAMA,
M Depiante-Depaoli, and C M Riera, and C Yantorno, and A Risemberg, and A Strussberg
Antinucleosome antibodies in the diagnosis of systemic lupus erythematosus.
March 2003, Annals of the rheumatic diseases,
M Depiante-Depaoli, and C M Riera, and C Yantorno, and A Risemberg, and A Strussberg
Antibodies to DNA in childhood systemic lupus erythematosus.
June 1971, The Journal of pediatrics,
M Depiante-Depaoli, and C M Riera, and C Yantorno, and A Risemberg, and A Strussberg
Specificities of antinuclear antibodies detected in dogs with systemic lupus erythematosus.
October 1984, Veterinary immunology and immunopathology,
Copied contents to your clipboard!