Cytological and histopathological correlation of thyroid lesions. 2022

Madiha Syed, and Noreen Akhtar, and Maryam Hameed, and Sajid Mushtaq, and Asif Loya, and Usman Hassan, and Muddassar Hussain
Department of Histopathology and Cytopathology, Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan.

OBJECTIVE To determine accuracy of cytological diagnosis in comparison with the corresponding histopathological diagnosis of thyroid lesions. METHODS The retrospective study was conducted at the Shaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan, and comprised data from January to December 2017 of all in-patient cases of thyroid cytology with their histopathological diagnosis. Both Haematoxylin and Eosin stain slides and cytological smears were reviewed. True negative, true positive, false negative and false positive cases were marked using the criteria defined in Table-1. RESULTS Of the total 36 cases, 5(13.9%) were non-diagnostic or unsatisfactory for cytological assessment. Cytological diagnosis achieved sensitivity of 82.3%, specificity 64.3%, positive predictive value 73.6%, negative predictive value 75%, false positive rate 35.7% and false negative rate 17.6%. The diagnostic accuracy of cytological diagnosis was 63.9%. CONCLUSIONS There was significant cytological and histopathological concordance of thyroid lesions.

UI MeSH Term Description Entries
D003581 Cytodiagnosis Diagnosis of the type and, when feasible, the cause of a pathologic process by means of microscopic study of cells in an exudate or other form of body fluid. (Stedman, 26th ed) Cytodiagnoses
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012189 Retrospective Studies Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. Retrospective Study,Studies, Retrospective,Study, Retrospective
D012680 Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed) Specificity,Sensitivity,Specificity and Sensitivity
D013961 Thyroid Gland A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively. Thyroid,Gland, Thyroid,Glands, Thyroid,Thyroid Glands,Thyroids
D044963 Biopsy, Fine-Needle Using fine needles (finer than 22-gauge) to remove tissue or fluid specimens from the living body for examination in the pathology laboratory and for disease diagnosis. Aspiration Biopsy, Fine-Needle,Fine Needle Biopsy,Fine-Needle Aspiration,Aspiration Biopsies, Fine-Needle,Aspiration Biopsy, Fine Needle,Aspiration, Fine-Needle,Aspirations, Fine-Needle,Biopsies, Fine Needle,Biopsies, Fine-Needle,Biopsies, Fine-Needle Aspiration,Biopsy, Fine Needle,Biopsy, Fine-Needle Aspiration,Fine Needle Aspiration,Fine Needle Biopsies,Fine-Needle Aspiration Biopsies,Fine-Needle Aspiration Biopsy,Fine-Needle Aspirations,Fine-Needle Biopsies,Fine-Needle Biopsy,Needle Biopsies, Fine,Needle Biopsy, Fine

Related Publications

Madiha Syed, and Noreen Akhtar, and Maryam Hameed, and Sajid Mushtaq, and Asif Loya, and Usman Hassan, and Muddassar Hussain
March 2008, Journal of the Egyptian National Cancer Institute,
Madiha Syed, and Noreen Akhtar, and Maryam Hameed, and Sajid Mushtaq, and Asif Loya, and Usman Hassan, and Muddassar Hussain
January 1979, La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris,
Madiha Syed, and Noreen Akhtar, and Maryam Hameed, and Sajid Mushtaq, and Asif Loya, and Usman Hassan, and Muddassar Hussain
January 1978, Archives d'anatomie et de cytologie pathologiques,
Madiha Syed, and Noreen Akhtar, and Maryam Hameed, and Sajid Mushtaq, and Asif Loya, and Usman Hassan, and Muddassar Hussain
January 2018, Journal of cytology,
Madiha Syed, and Noreen Akhtar, and Maryam Hameed, and Sajid Mushtaq, and Asif Loya, and Usman Hassan, and Muddassar Hussain
October 1987, The Journal of urology,
Madiha Syed, and Noreen Akhtar, and Maryam Hameed, and Sajid Mushtaq, and Asif Loya, and Usman Hassan, and Muddassar Hussain
January 1972, Ugeskrift for laeger,
Madiha Syed, and Noreen Akhtar, and Maryam Hameed, and Sajid Mushtaq, and Asif Loya, and Usman Hassan, and Muddassar Hussain
January 2010, Current health sciences journal,
Madiha Syed, and Noreen Akhtar, and Maryam Hameed, and Sajid Mushtaq, and Asif Loya, and Usman Hassan, and Muddassar Hussain
January 2018, Journal of cytology,
Madiha Syed, and Noreen Akhtar, and Maryam Hameed, and Sajid Mushtaq, and Asif Loya, and Usman Hassan, and Muddassar Hussain
October 1987, Indian journal of pathology & microbiology,
Madiha Syed, and Noreen Akhtar, and Maryam Hameed, and Sajid Mushtaq, and Asif Loya, and Usman Hassan, and Muddassar Hussain
February 2014, The Indian journal of surgery,
Copied contents to your clipboard!