A Novel Cognition of Decitabine: Insights into Immunomodulation and Antiviral Effects. 2022

Ji Xiao, and Ping Liu, and Yiliang Wang, and Yexuan Zhu, and Qiongzhen Zeng, and Xiao Hu, and Zhe Ren, and Yifei Wang
Jinan Biomedicine Research and Development Center, Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.

DNA methylation, as one of the major means of epigenesis change, makes a large difference in the spatial structure of chromatin, transposable element activity and, fundamentally, gene transcription. It has been confirmed that DNA methylation is closely related to innate immune responses. Decitabine, the most efficient available DNA methyltransferase inhibitor, has demonstrated exhilarating immune activation and antiviral effects on multiple viruses, including HIV, HBV, HCV, HPV and EHV1. This review considers the role of decitabine in regulating innate immune responses and antiviral ability. Understanding the complex transcriptional and immune regulation of decitabine could help to identify and validate therapeutic methods to reduce pathogen infection-associated morbidity, especially virus infection-induced morbidity and mortality.

UI MeSH Term Description Entries
D007113 Immunity, Innate The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS. Immunity, Native,Immunity, Natural,Immunity, Non-Specific,Resistance, Natural,Innate Immune Response,Innate Immunity,Immune Response, Innate,Immune Responses, Innate,Immunity, Non Specific,Innate Immune Responses,Native Immunity,Natural Immunity,Natural Resistance,Non-Specific Immunity
D003071 Cognition Intellectual or mental process whereby an organism obtains knowledge. Cognitive Function,Cognitions,Cognitive Functions,Function, Cognitive,Functions, Cognitive
D000077209 Decitabine An azacitidine derivative and antineoplastic antimetabolite. It inhibits DNA methyltransferase to re-activate silent genes, limiting METASTASIS and NEOPLASM DRUG RESISTANCE. Decitabine is used in the treatment of MYELODISPLASTIC SYNDROMES, and ACUTE MYELOID LEUKEMIA. 2'-Deoxy-5-azacytidine,5-Aza-2'-deoxycytidine,5-AzadC,5-Azadeoxycytidine,5-Deoxyazacytidine,5AzadC,AzadC Compound,Dacogen,Decitabine Mesylate,NSC 127716,NSC-127716,2' Deoxy 5 azacytidine,5 Aza 2' deoxycytidine,5 Azadeoxycytidine,5 Deoxyazacytidine,Compound, AzadC,Mesylate, Decitabine,NSC127716
D000998 Antiviral Agents Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. Antiviral,Antiviral Agent,Antiviral Drug,Antivirals,Antiviral Drugs,Agent, Antiviral,Agents, Antiviral,Drug, Antiviral,Drugs, Antiviral
D056747 Immunomodulation Alteration of the immune system or of an immune response by agents that activate or suppress its function. This can include IMMUNIZATION or administration of immunomodulatory drugs. Immunomodulation can also encompass non-therapeutic alteration of the immune system effected by endogenous or exogenous substances. Immunomodulatory Therapy,Immunomodulations,Immunomodulatory Therapies,Therapies, Immunomodulatory,Therapy, Immunomodulatory

Related Publications

Ji Xiao, and Ping Liu, and Yiliang Wang, and Yexuan Zhu, and Qiongzhen Zeng, and Xiao Hu, and Zhe Ren, and Yifei Wang
October 2014, Seminars in cancer biology,
Ji Xiao, and Ping Liu, and Yiliang Wang, and Yexuan Zhu, and Qiongzhen Zeng, and Xiao Hu, and Zhe Ren, and Yifei Wang
January 2021, Frontiers in immunology,
Ji Xiao, and Ping Liu, and Yiliang Wang, and Yexuan Zhu, and Qiongzhen Zeng, and Xiao Hu, and Zhe Ren, and Yifei Wang
February 2021, Medicina (Kaunas, Lithuania),
Ji Xiao, and Ping Liu, and Yiliang Wang, and Yexuan Zhu, and Qiongzhen Zeng, and Xiao Hu, and Zhe Ren, and Yifei Wang
February 2006, The Lancet. Infectious diseases,
Ji Xiao, and Ping Liu, and Yiliang Wang, and Yexuan Zhu, and Qiongzhen Zeng, and Xiao Hu, and Zhe Ren, and Yifei Wang
August 2014, NeuroImage,
Ji Xiao, and Ping Liu, and Yiliang Wang, and Yexuan Zhu, and Qiongzhen Zeng, and Xiao Hu, and Zhe Ren, and Yifei Wang
January 1985, Developments in biological standardization,
Ji Xiao, and Ping Liu, and Yiliang Wang, and Yexuan Zhu, and Qiongzhen Zeng, and Xiao Hu, and Zhe Ren, and Yifei Wang
November 2013, Brain research,
Ji Xiao, and Ping Liu, and Yiliang Wang, and Yexuan Zhu, and Qiongzhen Zeng, and Xiao Hu, and Zhe Ren, and Yifei Wang
February 2015, Cognition,
Ji Xiao, and Ping Liu, and Yiliang Wang, and Yexuan Zhu, and Qiongzhen Zeng, and Xiao Hu, and Zhe Ren, and Yifei Wang
April 2004, Developmental science,
Ji Xiao, and Ping Liu, and Yiliang Wang, and Yexuan Zhu, and Qiongzhen Zeng, and Xiao Hu, and Zhe Ren, and Yifei Wang
April 2024, Journal of neuroendocrinology,
Copied contents to your clipboard!