Molar-incisor malformation (MIM) is a newly described dental developmental anomaly that predominantly affects primary second molars, permanent first molars, and, in some cases, permanent central incisors. Diagnosis is usually made upon radiographic examination. The molars usually present with significant cervical constriction, flattened pulp chambers, and absent or thin, short, and narrow roots, whereas the incisors usually exhibit coronal dilaceration. Loss of these compromised teeth in the long term may be inevitable. Thus, clinicians should be aware of this condition and the factors to consider to advise their patients as early as possible. The purpose of this paper is to present two cases of MIM and discuss the factors clinicians should take into consideration to make a care plan in these cases.