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The predictive value of the dexamethasone suppression test (DST) was evaluated in two consecutive double-blind, placebo-controlled trials evaluating 61 depressed inpatients randomized to either one of two drugs, sertraline or oxaprotiline, or placebo over a 4-week clinical trial. For 30 patients who completed at least 3 weeks of double-blind treatment on either drug, the initial DST was not predictive of response to drug treatment. For the 17 patients who completed at least 3 weeks of double-blind treatment on placebo, the presence of a positive DST predicted a statistically significantly poorer response to placebo as opposed to a negative DST. These preliminary findings suggest that for depressed individuals who present with a positive DST, remission without active medication is less likely and somatic treatment should be considered.
E D Peselow, and
A Lautin, and
A Wolkin, and
C Rohrs, and
A Novatt, and
J Siekierski, and
J Rotrosen
March 1989,
The Journal of clinical psychiatry,
E D Peselow, and
A Lautin, and
A Wolkin, and
C Rohrs, and
A Novatt, and
J Siekierski, and
J Rotrosen
September 1984,
The Journal of clinical psychiatry,
E D Peselow, and
A Lautin, and
A Wolkin, and
C Rohrs, and
A Novatt, and
J Siekierski, and
J Rotrosen
December 1981,
The American journal of psychiatry,
E D Peselow, and
A Lautin, and
A Wolkin, and
C Rohrs, and
A Novatt, and
J Siekierski, and
J Rotrosen
January 1982,
Medizinische Klinik (Klinik-Ausg.),
E D Peselow, and
A Lautin, and
A Wolkin, and
C Rohrs, and
A Novatt, and
J Siekierski, and
J Rotrosen
January 1986,
The Journal of clinical psychiatry,
E D Peselow, and
A Lautin, and
A Wolkin, and
C Rohrs, and
A Novatt, and
J Siekierski, and
J Rotrosen
April 1984,
The British journal of psychiatry : the journal of mental science,
E D Peselow, and
A Lautin, and
A Wolkin, and
C Rohrs, and
A Novatt, and
J Siekierski, and
J Rotrosen
November 1982,
The New England journal of medicine,
E D Peselow, and
A Lautin, and
A Wolkin, and
C Rohrs, and
A Novatt, and
J Siekierski, and
J Rotrosen
January 1989,
European neurology,
E D Peselow, and
A Lautin, and
A Wolkin, and
C Rohrs, and
A Novatt, and
J Siekierski, and
J Rotrosen
August 1984,
The British journal of psychiatry : the journal of mental science,
E D Peselow, and
A Lautin, and
A Wolkin, and
C Rohrs, and
A Novatt, and
J Siekierski, and
J Rotrosen
January 1986,
Journal of affective disorders,
