-transparent.png){kind=logo}
Immunohistochemical localization of ornithine aminotransferase (L-ornithine: 2-oxo-acid aminotransferase, EC 2.6.1.13), a mitochondrial enzyme whose hereditary absence induces gyrate atrophy of the choroid and retina, was elucidated by a direct immunoperoxidase method using Fab'-horseradish peroxidase conjugates. In immunodiffusion studies, the antibodies raised with the re-crystallized enzyme were highly specific to ornithine aminotransferase. To show localization of ornithine aminotransferase in normal rat tissues, clear immunohistochemical staining of this enzyme through the inner mitochondrial membrane in paraffin sections was achieved with Fab'-horseradish peroxidase conjugates. Strong immunoreactivity was present in cerebral neurons, hepatocytes, and epithelial cells of renal tubuli, gut mucous membranes, and ocular tissues. Specific distribution of ornithine aminotransferase was found in ependymal cell groups: namely, epithelial cells of the choroid plexus, pigmented and nonpigmented epithelial cells of the ciliary body. and Müller cells and pigment epithelium of the retina.
M Kasahara, and
T Matsuzawa, and
M Kokubo, and
Y Gushiken, and
K Tashiro, and
T Koide, and
H Watanabe, and
N Katunuma
January 1987,
Progress in clinical and biological research,
M Kasahara, and
T Matsuzawa, and
M Kokubo, and
Y Gushiken, and
K Tashiro, and
T Koide, and
H Watanabe, and
N Katunuma
September 1987,
Investigative ophthalmology & visual science,
M Kasahara, and
T Matsuzawa, and
M Kokubo, and
Y Gushiken, and
K Tashiro, and
T Koide, and
H Watanabe, and
N Katunuma
January 1985,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
M Kasahara, and
T Matsuzawa, and
M Kokubo, and
Y Gushiken, and
K Tashiro, and
T Koide, and
H Watanabe, and
N Katunuma
September 1989,
Archives of ophthalmology (Chicago, Ill. : 1960),
M Kasahara, and
T Matsuzawa, and
M Kokubo, and
Y Gushiken, and
K Tashiro, and
T Koide, and
H Watanabe, and
N Katunuma
April 1970,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
M Kasahara, and
T Matsuzawa, and
M Kokubo, and
Y Gushiken, and
K Tashiro, and
T Koide, and
H Watanabe, and
N Katunuma
July 2011,
Acta naturae,
M Kasahara, and
T Matsuzawa, and
M Kokubo, and
Y Gushiken, and
K Tashiro, and
T Koide, and
H Watanabe, and
N Katunuma
June 1974,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
M Kasahara, and
T Matsuzawa, and
M Kokubo, and
Y Gushiken, and
K Tashiro, and
T Koide, and
H Watanabe, and
N Katunuma
December 1969,
ANL,
M Kasahara, and
T Matsuzawa, and
M Kokubo, and
Y Gushiken, and
K Tashiro, and
T Koide, and
H Watanabe, and
N Katunuma
May 1989,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
M Kasahara, and
T Matsuzawa, and
M Kokubo, and
Y Gushiken, and
K Tashiro, and
T Koide, and
H Watanabe, and
N Katunuma
July 1978,
Brain research,
