This paper studied the pathological features of 78 cases of primary gastrointestinal lymphoma. All patients with primary gastrointestinal lymphoma diagnosed in PET Center of Zhebei Mingzhou Hospital in Huzhou from August 2013 to April 2021 were analyzed retrospectively. In addition, the pathology and immunohistochemistry of these patients were retrieved from the inpatient system of Huzhou Central Hospital. The results showed that the male-female ratio of these 78 patients was about 1.29/1 (including 44 males and 34 females), with a median age of 63 years old (20-90 years old). The most frequent sites in order of its occurrence were the stomach (51.3%), small intestine (34.6%), ileocecal region (9%) and colon (5.1%). T-cell lymphoma accounted for 10.7% of primary gastrointestinal lymphoma, and all of them were found in small intestines, while B-cell lymphoma accounted for 89.3%.