BIOMAT Database Logo BIOMAT Database Logo

Localization of 125I-insulin binding sites in the rat hypothalamus by quantitative autoradiography. 1986

E S Corp, and S C Woods, and D Porte, and D M Dorsa, and D P Figlewicz, and D G Baskin

In vitro autoradiography and computer video densitometry were used to localize and quantify binding of 125I-insulin in the hypothalamus of the rat brain. Highest specific binding was found in the arcuate, dorsomedial, suprachiasmatic, paraventricular and periventricular regions. Significantly lower binding was present in the ventromedial nucleus and median eminence. The results are consistent with the hypothesis that insulin modulates the neural regulation of feeding by acting at sites in the hypothalamus.

UI MeSH Term Description Entries
D007031 Hypothalamus Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE. Lamina Terminalis,Preoptico-Hypothalamic Area,Area, Preoptico-Hypothalamic,Areas, Preoptico-Hypothalamic,Preoptico Hypothalamic Area,Preoptico-Hypothalamic Areas
D007328 Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D008297 Male Males
D001835 Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. Body Weights,Weight, Body,Weights, Body
D001931 Brain Mapping Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures. Brain Electrical Activity Mapping,Functional Cerebral Localization,Topographic Brain Mapping,Brain Mapping, Topographic,Functional Cerebral Localizations,Mapping, Brain,Mapping, Topographic Brain
D005247 Feeding Behavior Behavioral responses or sequences associated with eating including modes of feeding, rhythmic patterns of eating, and time intervals. Dietary Habits,Eating Behavior,Faith-based Dietary Restrictions,Feeding Patterns,Feeding-Related Behavior,Food Habits,Diet Habits,Eating Habits,Behavior, Eating,Behavior, Feeding,Behavior, Feeding-Related,Behaviors, Eating,Behaviors, Feeding,Behaviors, Feeding-Related,Diet Habit,Dietary Habit,Dietary Restriction, Faith-based,Dietary Restrictions, Faith-based,Eating Behaviors,Eating Habit,Faith based Dietary Restrictions,Faith-based Dietary Restriction,Feeding Behaviors,Feeding Pattern,Feeding Related Behavior,Feeding-Related Behaviors,Food Habit,Habit, Diet,Habit, Dietary,Habit, Eating,Habit, Food,Habits, Diet,Pattern, Feeding,Patterns, Feeding,Restrictions, Faith-based Dietary
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001345 Autoradiography The making of a radiograph of an object or tissue by recording on a photographic plate the radiation emitted by radioactive material within the object. (Dorland, 27th ed) Radioautography
D001665 Binding Sites The parts of a macromolecule that directly participate in its specific combination with another molecule. Combining Site,Binding Site,Combining Sites,Site, Binding,Site, Combining,Sites, Binding,Sites, Combining

Related Publications

E S Corp, and S C Woods, and D Porte, and D M Dorsa, and D P Figlewicz, and D G Baskin
Localization and characterization by quantitative autoradiography of [125I]LSD binding sites in rat brain.
August 1984, Neuroscience letters,
E S Corp, and S C Woods, and D Porte, and D M Dorsa, and D P Figlewicz, and D G Baskin
Localization of binding sites for insulin-like growth factor-I (IGF-I) in the rat brain by quantitative autoradiography.
March 1988, Brain research,
E S Corp, and S C Woods, and D Porte, and D M Dorsa, and D P Figlewicz, and D G Baskin
Localization and characterization of [3H]desmethylimipramine binding sites in rat brain by quantitative autoradiography.
May 1983, The Journal of neuroscience : the official journal of the Society for Neuroscience,
E S Corp, and S C Woods, and D Porte, and D M Dorsa, and D P Figlewicz, and D G Baskin
Localization of [3H]forskolin binding sites in the rat brain using quantitative autoradiography.
October 1984, European journal of pharmacology,
E S Corp, and S C Woods, and D Porte, and D M Dorsa, and D P Figlewicz, and D G Baskin
Quantitative autoradiography of [125I] apamin binding sites in the central nervous system.
January 1984, Biomedica biochimica acta,
E S Corp, and S C Woods, and D Porte, and D M Dorsa, and D P Figlewicz, and D G Baskin
Ontogeny and characterization of [125I]Bolton Hunter-eledoisin binding sites in rat spinal cord by quantitative autoradiography.
January 1992, Neuroscience,
E S Corp, and S C Woods, and D Porte, and D M Dorsa, and D P Figlewicz, and D G Baskin
Quantitative autoradiographic localization of [125I]insulin-like growth factor I, [125I]insulin-like growth factor II, and [125I]insulin receptor binding sites in developing and adult rat brain.
July 1993, The Journal of comparative neurology,
E S Corp, and S C Woods, and D Porte, and D M Dorsa, and D P Figlewicz, and D G Baskin
Pharmacological analysis of 125I-Bolton and Hunter labelled eledoisin binding sites in rat spinal cord by quantitative autoradiography.
July 1987, Neuroscience letters,
E S Corp, and S C Woods, and D Porte, and D M Dorsa, and D P Figlewicz, and D G Baskin
Localization of prolactin binding sites in ring dove brain by quantitative autoradiography.
May 1989, Brain research,
E S Corp, and S C Woods, and D Porte, and D M Dorsa, and D P Figlewicz, and D G Baskin
Localization of L-glutamate binding sites in chick brain by quantitative autoradiography.
April 1990, Brain research,
Copied contents to your clipboard!