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Fifty-five patients with endoscopically confirmed gastric ulcers received either cimetidine (28 patients) or pirenzepine (27 patients) in a randomized double-blind manner. Fifty-seven per cent of the patients treated with cimetidine and 48% of those treated with pirenzepine presented with endoscopically healed ulcers after 4 weeks of treatment. By 8 weeks complete healing had occurred in 83% of the patients taking cimetidine and 76% of those taking pirenzepine. These differences were not statistically significant. Severity of pain on entering the study was correlated with slower healing of the ulcer. Side effects occurred in 5 of 27 patients in the pirenzepine group and 3 of 28 in the cimetidine group. They were mostly mild and did not differ from side effects observed in other studies.
J J Gonvers, and
S Realini, and
A Bretholz, and
M Voirol, and
J Arnold, and
R Birchler, and
J B Ollyo, and
J Guyot, and
Y Capitaine
October 1987,
Hepato-gastroenterology,
J J Gonvers, and
S Realini, and
A Bretholz, and
M Voirol, and
J Arnold, and
R Birchler, and
J B Ollyo, and
J Guyot, and
Y Capitaine
January 1982,
Digestion,
J J Gonvers, and
S Realini, and
A Bretholz, and
M Voirol, and
J Arnold, and
R Birchler, and
J B Ollyo, and
J Guyot, and
Y Capitaine
January 1988,
Digestion,
J J Gonvers, and
S Realini, and
A Bretholz, and
M Voirol, and
J Arnold, and
R Birchler, and
J B Ollyo, and
J Guyot, and
Y Capitaine
February 1978,
Gastroenterology,
J J Gonvers, and
S Realini, and
A Bretholz, and
M Voirol, and
J Arnold, and
R Birchler, and
J B Ollyo, and
J Guyot, and
Y Capitaine
July 1982,
La Clinica terapeutica,
J J Gonvers, and
S Realini, and
A Bretholz, and
M Voirol, and
J Arnold, and
R Birchler, and
J B Ollyo, and
J Guyot, and
Y Capitaine
June 1983,
The New England journal of medicine,
J J Gonvers, and
S Realini, and
A Bretholz, and
M Voirol, and
J Arnold, and
R Birchler, and
J B Ollyo, and
J Guyot, and
Y Capitaine
January 1986,
Scandinavian journal of gastroenterology. Supplement,
J J Gonvers, and
S Realini, and
A Bretholz, and
M Voirol, and
J Arnold, and
R Birchler, and
J B Ollyo, and
J Guyot, and
Y Capitaine
November 1988,
Zeitschrift fur Gastroenterologie,
J J Gonvers, and
S Realini, and
A Bretholz, and
M Voirol, and
J Arnold, and
R Birchler, and
J B Ollyo, and
J Guyot, and
Y Capitaine
July 1979,
The Medical journal of Australia,
J J Gonvers, and
S Realini, and
A Bretholz, and
M Voirol, and
J Arnold, and
R Birchler, and
J B Ollyo, and
J Guyot, and
Y Capitaine
December 1981,
The American journal of gastroenterology,
