BIOMAT Database Logo BIOMAT Database Logo

Transcutaneous carbon dioxide monitoring during therapeutic hypothermia for neonatal encephalopathy. 2022

Norani H Gangaram-Panday, and Tanja van Essen, and Willem van Weteringen, and Marjolein H G Dremmen, and Tom G Goos, and Rogier C J de Jonge, and Irwin K M Reiss
Department of Pediatrics, Division of Neonatology, Erasmus MC Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands. n.gangaram-panday@erasmusmc.nl.

In neonates with post-asphyxial neonatal encephalopathy, further neuronal damage is prevented with therapeutic hypothermia (TH). In addition, fluctuations in carbon dioxide levels have been associated with poor neurodevelopmental outcome, demanding close monitoring. This study investigated the accuracy and clinical value of transcutaneous carbon dioxide (tcPCO2) monitoring during TH. In this retrospective cohort study in neonates, agreement between arterial carbon dioxide (PaCO2) values and tcPCO2 measurements during TH was determined. TcPCO2 levels during the first 24 h of hypothermia were tested for an association with ischemic brain injury on magnetic resonance imaging (MRI). Thirty-four neonates were included. Agreement (bias (95% limits of agreement)) between tcPCO2 and PaCO2 levels was 3.9 (-12.4-20.2) mm Hg. No relation was found between the body temperature and tcPCO2 levels. TcPCO2 levels differed significantly between patients with considerable and minimal damage on MRI; after 6 h (P = 0.02) and 9 h (P = 0.04). Although tcPCO2 provided a limited estimation of PaCO2, it can be used for trend monitoring during TH. TcPCO2 levels after birth could provide an early indicator of ischemic brain injury. This relation should be investigated in large prospective studies, in which adjustments for confounders can be made. Transcutaneous carbon dioxide measurements during therapeutic hypothermia in neonates show limited accuracy similar to measurements reported in normothermic neonates and can be used for trend monitoring. Low transcutaneous carbon dioxide levels during the first 24 h were associated with considerable ischemic brain injury on MRI. The value of transcutaneous carbon dioxide measurements during the first 24 h as an indicator of considerable ischemic brain injury on MRI should be investigated in future studies, adjusting for confounders. Transcutaneous oxygen measurements during therapeutic hypothermia showed an inaccuracy that could not be related to a low body temperature.

UI MeSH Term Description Entries
D007036 Hypothermia, Induced Abnormally low BODY TEMPERATURE that is intentionally induced in warm-blooded animals by artificial means. In humans, mild or moderate hypothermia has been used to reduce tissue damages, particularly after cardiac or spinal cord injuries and during subsequent surgeries. Induced Hypothermia,Mild Hypothermia, Induced,Moderate Hypothermia, Induced,Targeted Temperature Management,Therapeutic Hypothermia,Hypothermia, Therapeutic,Induced Mild Hypothermia,Induced Mild Hypothermias,Induced Moderate Hypothermia,Induced Moderate Hypothermias,Mild Hypothermias, Induced,Moderate Hypothermias, Induced,Targeted Temperature Managements
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D007232 Infant, Newborn, Diseases Diseases of newborn infants present at birth (congenital) or developing within the first month of birth. It does not include hereditary diseases not manifesting at birth or within the first 30 days of life nor does it include inborn errors of metabolism. Both HEREDITARY DISEASES and METABOLISM, INBORN ERRORS are available as general concepts. Neonatal Diseases,Disease, Neonatal,Diseases, Neonatal,Neonatal Disease
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D012120 Respiration Disorders Diseases of the respiratory system in general or unspecified or for a specific respiratory disease not available. Disorder, Respiration,Disorders, Respiration,Respiration Disorder
D001785 Blood Gas Monitoring, Transcutaneous The noninvasive measurement or determination of the partial pressure (tension) of oxygen and/or carbon dioxide locally in the capillaries of a tissue by the application to the skin of a special set of electrodes. These electrodes contain photoelectric sensors capable of picking up the specific wavelengths of radiation emitted by oxygenated versus reduced hemoglobin. Carbon Dioxide Partial Pressure Determination, Transcutaneous,Cutaneous Oximetry,Oximetry, Transcutaneous,Oxygen Partial Pressure Determination, Transcutaneous,Transcutaneous Blood Gas Monitoring,Transcutaneous Capnometry,Transcutaneous Oximetry,PtcO2,TcPCO2,Capnometries, Transcutaneous,Capnometry, Transcutaneous,Cutaneous Oximetries,Oximetries, Cutaneous,Oximetries, Transcutaneous,Oximetry, Cutaneous,Transcutaneous Capnometries,Transcutaneous Oximetries
D001930 Brain Injuries Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits. Brain Lacerations,Acute Brain Injuries,Brain Injuries, Acute,Brain Injuries, Focal,Focal Brain Injuries,Injuries, Acute Brain,Injuries, Brain,Acute Brain Injury,Brain Injury,Brain Injury, Acute,Brain Injury, Focal,Brain Laceration,Focal Brain Injury,Injuries, Focal Brain,Injury, Acute Brain,Injury, Brain,Injury, Focal Brain,Laceration, Brain,Lacerations, Brain
D002245 Carbon Dioxide A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals. Carbonic Anhydride,Anhydride, Carbonic,Dioxide, Carbon
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012189 Retrospective Studies Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. Retrospective Study,Studies, Retrospective,Study, Retrospective

Related Publications

Norani H Gangaram-Panday, and Tanja van Essen, and Willem van Weteringen, and Marjolein H G Dremmen, and Tom G Goos, and Rogier C J de Jonge, and Irwin K M Reiss
Transcutaneous carbon dioxide monitoring during neonatal transport.
December 1986, Critical care medicine,
Norani H Gangaram-Panday, and Tanja van Essen, and Willem van Weteringen, and Marjolein H G Dremmen, and Tom G Goos, and Rogier C J de Jonge, and Irwin K M Reiss
Monitoring of end tidal carbon dioxide and transcutaneous carbon dioxide during neonatal transport.
November 2005, Archives of disease in childhood. Fetal and neonatal edition,
Norani H Gangaram-Panday, and Tanja van Essen, and Willem van Weteringen, and Marjolein H G Dremmen, and Tom G Goos, and Rogier C J de Jonge, and Irwin K M Reiss
Therapeutic hypothermia for neonatal encephalopathy.
December 2012, Current treatment options in neurology,
Norani H Gangaram-Panday, and Tanja van Essen, and Willem van Weteringen, and Marjolein H G Dremmen, and Tom G Goos, and Rogier C J de Jonge, and Irwin K M Reiss
Therapeutic hypothermia for neonatal encephalopathy.
April 2015, Current opinion in pediatrics,
Norani H Gangaram-Panday, and Tanja van Essen, and Willem van Weteringen, and Marjolein H G Dremmen, and Tom G Goos, and Rogier C J de Jonge, and Irwin K M Reiss
Transcutaneous carbon dioxide monitoring.
August 2007, Anaesthesia,
Norani H Gangaram-Panday, and Tanja van Essen, and Willem van Weteringen, and Marjolein H G Dremmen, and Tom G Goos, and Rogier C J de Jonge, and Irwin K M Reiss
Transcutaneous carbon dioxide monitoring.
April 1990, Archives of disease in childhood,
Norani H Gangaram-Panday, and Tanja van Essen, and Willem van Weteringen, and Marjolein H G Dremmen, and Tom G Goos, and Rogier C J de Jonge, and Irwin K M Reiss
Transcutaneous carbon dioxide monitoring.
June 2006, Critical care nursing clinics of North America,
Norani H Gangaram-Panday, and Tanja van Essen, and Willem van Weteringen, and Marjolein H G Dremmen, and Tom G Goos, and Rogier C J de Jonge, and Irwin K M Reiss
Transcutaneous carbon dioxide monitoring.
August 1981, The American review of respiratory disease,
Norani H Gangaram-Panday, and Tanja van Essen, and Willem van Weteringen, and Marjolein H G Dremmen, and Tom G Goos, and Rogier C J de Jonge, and Irwin K M Reiss
Simultaneous transcutaneous carbon dioxide and transcutaneous oxygen monitoring in neonatal intensive care.
January 1983, Journal of perinatal medicine,
Norani H Gangaram-Panday, and Tanja van Essen, and Willem van Weteringen, and Marjolein H G Dremmen, and Tom G Goos, and Rogier C J de Jonge, and Irwin K M Reiss
[Transcutaneous monitoring of carbon dioxide tension during delivery].
November 1986, Ugeskrift for laeger,
Copied contents to your clipboard!