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Electrolytes are involved to a greater or lesser extent in the hypertension of probably all the inbred strains but it is difficult to sort out whether the involvement is primary or secondary and the detected abnormalities differ in the various strains. The fundamental faults are still elusive, except perhaps in the Dahl salt-sensitive rats, which appear to have a form of mineralocorticoid hypertension. Sodium and calcium appear to be the electrolytes most closely implicated in the pathogenesis of hypertension but potassium, magnesium and chloride should not be neglected. More data are needed. Knowledge gained from rat studies is useful in the context of both basic physiology and human hypertension.
F O Simpson, and
J Ledingham, and
E L Phelan
June 1970,
Japanese circulation journal,
F O Simpson, and
J Ledingham, and
E L Phelan
October 1975,
Kardiologiia,
F O Simpson, and
J Ledingham, and
E L Phelan
January 1969,
International review of experimental pathology,
F O Simpson, and
J Ledingham, and
E L Phelan
April 1979,
Biulleten' eksperimental'noi biologii i meditsiny,
F O Simpson, and
J Ledingham, and
E L Phelan
March 1986,
Life sciences,
F O Simpson, and
J Ledingham, and
E L Phelan
February 1986,
Zhonghua xin xue guan bing za zhi,
F O Simpson, and
J Ledingham, and
E L Phelan
June 1976,
Biulleten' eksperimental'noi biologii i meditsiny,
F O Simpson, and
J Ledingham, and
E L Phelan
December 1954,
Journal de medecine de Lyon,
F O Simpson, and
J Ledingham, and
E L Phelan
May 1952,
Archiv fur Kreislaufforschung,
F O Simpson, and
J Ledingham, and
E L Phelan
January 1985,
Annals of clinical research,
