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Plasma renin activity (PRA) was studied serially for up to 21 days following transplantation in thirteen patients receiving renal allografts. PRA was measured during fasting and recumvency and its relationship to renal function, diuretic administration, plasma sodium, allograft rejection and blood pressure was examined. PRA fell steadily as renal function improved and plasma sodium rose following transplantation and when rejection episodes were excluded an inverse relationship between PRA and renal function could be seen. It is not possible to say whether the changes in PRA and function are causally related or whether changes in plasma sodium alone account for the observed changes in PRA. Some rejection episodes were accompanied by an increase in PRA, but this was not sufficiently consistent to be of value in the diagnosis of rejection. PRA also increased in relation to frusemide-induced fluid loss. There was no relationship in these patients between PRA and blood pressure.
M H Snow, and
S J Jachuck, and
V Robson, and
R Wilkinson
August 1987,
The Indian journal of medical research,
M H Snow, and
S J Jachuck, and
V Robson, and
R Wilkinson
June 1975,
Clinical science and molecular medicine. Supplement,
M H Snow, and
S J Jachuck, and
V Robson, and
R Wilkinson
July 1981,
Clinical science (London, England : 1979),
M H Snow, and
S J Jachuck, and
V Robson, and
R Wilkinson
January 1974,
Kidney international,
M H Snow, and
S J Jachuck, and
V Robson, and
R Wilkinson
December 1976,
Clinical science and molecular medicine. Supplement,
M H Snow, and
S J Jachuck, and
V Robson, and
R Wilkinson
May 1973,
Transplantation,
M H Snow, and
S J Jachuck, and
V Robson, and
R Wilkinson
January 1978,
Vnitrni lekarstvi,
M H Snow, and
S J Jachuck, and
V Robson, and
R Wilkinson
January 1969,
Nephron,
M H Snow, and
S J Jachuck, and
V Robson, and
R Wilkinson
May 1971,
Southern medical journal,
M H Snow, and
S J Jachuck, and
V Robson, and
R Wilkinson
January 1972,
Pflugers Archiv : European journal of physiology,
