-transparent.png){kind=logo}
Prostaglandin (PG) I2 and its stable metabolite, 6-keto-PGF1alpha, were tested on the isolated ductus arteriosus from mature fetal lambs. PGI2 relaxed the ductus in high doses (threshold 10(-6)M) and its activity disappeared on standing at room temperature for 30 minutes. 6-keto-PGF1alpha was inactive at all doses. By contrast, PGE2 produced a dose-dependent relaxation over a range between 10(-10) and 10(-6)M. These findings confirm that PGE2 is the most potent ductal relaxant among the known derivatives of arachidonic acid. PGE2 probably maintains ductus patency in the fetus and, together with PGE1, remains the compound of choice in the management of newborns requiring a viable ductus for survival.
F Coceani, and
E Bodach, and
E White, and
I Bishai, and
P M Olley
January 1981,
The Journal of pediatrics,
F Coceani, and
E Bodach, and
E White, and
I Bishai, and
P M Olley
June 1986,
Canadian journal of physiology and pharmacology,
F Coceani, and
E Bodach, and
E White, and
I Bishai, and
P M Olley
December 2018,
Circulation journal : official journal of the Japanese Circulation Society,
F Coceani, and
E Bodach, and
E White, and
I Bishai, and
P M Olley
March 1980,
Prostaglandins,
F Coceani, and
E Bodach, and
E White, and
I Bishai, and
P M Olley
May 2004,
American journal of physiology. Regulatory, integrative and comparative physiology,
F Coceani, and
E Bodach, and
E White, and
I Bishai, and
P M Olley
June 1983,
The Journal of pediatrics,
F Coceani, and
E Bodach, and
E White, and
I Bishai, and
P M Olley
January 2014,
Circulation,
F Coceani, and
E Bodach, and
E White, and
I Bishai, and
P M Olley
January 1983,
Advances in prostaglandin, thromboxane, and leukotriene research,
F Coceani, and
E Bodach, and
E White, and
I Bishai, and
P M Olley
January 1989,
Circulation research,
F Coceani, and
E Bodach, and
E White, and
I Bishai, and
P M Olley
April 1978,
Biochimica et biophysica acta,
