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Prostaglandin I2 potentiated the paw swelling induced by carrageenin in rats. Prostaglandin I2 (0.1 microgram) showed similar activity to PGE1 (0.01 microgram). This potentiating property disappeared in 60 minutes and was completely abolished by diphenhydramine (25 mg kg-1, i.p.). In vascular permeability tests, PGI2 itself (2.5 X 10(-10) mol, 88 ng) caused no dye leakage reaction, but PGE1 (2.5 X 10(-10) mol, 88.5 ng) caused a significant dye leakage. This effect of PGE1 was statistically significant compared with vehicle- or PGI2-treated groups (p less than 0.05). Prostaglandin I2 potentiated the increased vascular permeability induced by 5-hydroxytriptamine (2.5 X 10(-10) mol), bradykinin (5 X 10(-10) mol) and histamine (2 X 10(-10) to 2 X 10(-8) mol). The potentiation was the most evident in the case of histamine.
K Komoriya, and
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K C Nicolaou, and
W E Barnette, and
R L Magolda
January 1986,
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March 1979,
British journal of pharmacology,
K Komoriya, and
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September 1990,
Digestive diseases and sciences,
K Komoriya, and
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March 1990,
Thrombosis research,
K Komoriya, and
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November 1993,
Hypertension (Dallas, Tex. : 1979),
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October 1984,
Prostaglandins, leukotrienes, and medicine,
K Komoriya, and
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K C Nicolaou, and
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January 1980,
Canadian Medical Association journal,
K Komoriya, and
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Y Hashimoto, and
K C Nicolaou, and
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November 1984,
The American journal of physiology,
K Komoriya, and
H Ohmori, and
A Azuma, and
S Kurozumi, and
Y Hashimoto, and
K C Nicolaou, and
W E Barnette, and
R L Magolda
November 1980,
Prostaglandins,
K Komoriya, and
H Ohmori, and
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Y Hashimoto, and
K C Nicolaou, and
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R L Magolda
August 1998,
Pancreas,
