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The persistent generalized lymphadenopathy (PGL) in drug addicts displays the same immunological abnormalities previously found in homosexual and haemophiliac men with PGL: impaired in vivo and in vitro T cell functions, inverted T4/T8 ratio in blood and B cell abnormalities. The peripheral blood B-lymphocytes, in fact, show a reduced in vitro immunoglobulin synthesis after pokeweed mitogen and Staphylococcus aureus activation, with an increased spontaneous IgG secretion. In the lymph node biopsies, the immuno-histological studies reveal an infiltration of OKT8 positive cells in the germinal centers, a depletion of OKT4 positive lymphocytes slighter than in the blood and an explosive follicular hyperplasia with a striking destruction of the dendritic reticulum cell framework. This latter finding, together with the high levels of serum IgG and the presence of preactivated B cells in the blood, seems to be consistent with the presence of an in vivo polyclonal B cell activation. A high incidence of anti-HTLV III antibodies was also found in the PGL drug addicts. The significance of these findings is discussed in this report.
W Barcellini, and
P L Meroni, and
A Lazzarin, and
C Sguotti, and
C Parravicini, and
M O Borghi, and
A Brucato, and
M Moroni, and
M C Sirianni, and
F Aiuti
January 1984,
Infection,
W Barcellini, and
P L Meroni, and
A Lazzarin, and
C Sguotti, and
C Parravicini, and
M O Borghi, and
A Brucato, and
M Moroni, and
M C Sirianni, and
F Aiuti
September 1984,
Bollettino dell'Istituto sieroterapico milanese,
W Barcellini, and
P L Meroni, and
A Lazzarin, and
C Sguotti, and
C Parravicini, and
M O Borghi, and
A Brucato, and
M Moroni, and
M C Sirianni, and
F Aiuti
April 1990,
Minerva medica,
W Barcellini, and
P L Meroni, and
A Lazzarin, and
C Sguotti, and
C Parravicini, and
M O Borghi, and
A Brucato, and
M Moroni, and
M C Sirianni, and
F Aiuti
January 1985,
Acta dermato-venereologica,
W Barcellini, and
P L Meroni, and
A Lazzarin, and
C Sguotti, and
C Parravicini, and
M O Borghi, and
A Brucato, and
M Moroni, and
M C Sirianni, and
F Aiuti
December 1990,
Anales de medicina interna (Madrid, Spain : 1984),
W Barcellini, and
P L Meroni, and
A Lazzarin, and
C Sguotti, and
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M O Borghi, and
A Brucato, and
M Moroni, and
M C Sirianni, and
F Aiuti
May 1990,
Medicina clinica,
W Barcellini, and
P L Meroni, and
A Lazzarin, and
C Sguotti, and
C Parravicini, and
M O Borghi, and
A Brucato, and
M Moroni, and
M C Sirianni, and
F Aiuti
June 1986,
Journal of clinical & laboratory immunology,
W Barcellini, and
P L Meroni, and
A Lazzarin, and
C Sguotti, and
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A Brucato, and
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September 1988,
Medicina clinica,
W Barcellini, and
P L Meroni, and
A Lazzarin, and
C Sguotti, and
C Parravicini, and
M O Borghi, and
A Brucato, and
M Moroni, and
M C Sirianni, and
F Aiuti
January 1986,
AIDS research,
W Barcellini, and
P L Meroni, and
A Lazzarin, and
C Sguotti, and
C Parravicini, and
M O Borghi, and
A Brucato, and
M Moroni, and
M C Sirianni, and
F Aiuti
May 1986,
Pathology, research and practice,
