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The efficacy of single daily doses of acebutolol, alone or combined with chlorexolone, was investigated in a group of 20 ambulant patients with uncomplicated hypertension of mild-to-moderate severity. severity. Patients were seen at fort-nightly intervals when doses were adjusted. Blood pressure was measured in all instances at 2 and 8 hours after medication, and after it had stabilized, at 26 hours after the last dose. The results indicate that a single dose of acebutolol alone produces significant lowering of supine and erect blood pressures for 24 hours (P less than 0,005). Combining chlorexolone with acebutolol does not improve the hypotensive effect of the beta-blocker significantly, but makes a smaller dose effective.
W P Leary, and
A C Asmal, and
P C Williams, and
B Marwick
October 1983,
Minerva medica,
W P Leary, and
A C Asmal, and
P C Williams, and
B Marwick
May 1985,
American heart journal,
W P Leary, and
A C Asmal, and
P C Williams, and
B Marwick
December 1977,
The Medical journal of Malaysia,
W P Leary, and
A C Asmal, and
P C Williams, and
B Marwick
January 1983,
Journal of cardiovascular pharmacology,
W P Leary, and
A C Asmal, and
P C Williams, and
B Marwick
January 1976,
Current medical research and opinion,
W P Leary, and
A C Asmal, and
P C Williams, and
B Marwick
January 1977,
The Journal of international medical research,
W P Leary, and
A C Asmal, and
P C Williams, and
B Marwick
January 1977,
Current medical research and opinion,
W P Leary, and
A C Asmal, and
P C Williams, and
B Marwick
December 1975,
La Nouvelle presse medicale,
W P Leary, and
A C Asmal, and
P C Williams, and
B Marwick
January 1981,
The Journal of international medical research,
W P Leary, and
A C Asmal, and
P C Williams, and
B Marwick
February 1982,
The Journal of the Association of Physicians of India,
