In this study, we investigated the effects of corn and rice extrusion diets on feed intake, nutrient digestibility, and gut microbiota in weaned piglets. Animals were divided into four dietary groups and fed a controlled diet containing (1) 62.17% corn (CORN), 15% soybean, 10% extruded full-fat soybean, and 6% fishmeal (2) half the corn replaced by extruded corn (ECORN), (3) broken rice (RICE), and (4) extruded broken rice (ERICE) for 28 days. Rice supplementation increased dry matter total tract digestibility and gross energy. Extruded cereals generated a lower average daily feed intake (ADFI) at 15-28 and 1-28 days, decreased average daily growth (ADG) at 15-28 and 1-28 days, and a lowered body weight (BW) on day 28, regardless of cereal type. Dietary extruded cereals increased the appetite-regulating hormones glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). Piglets fed extruded cereals displayed low short-chain fatty acid (SCFA) levels in plasma and low Lactobaillaceae and Bifidobateriaceae levels in feces, whereas a higher abundance of the potential pathogens Sarcina, Clostridium_sensu_strictio_1 and Terrisporobacter was observed. Piglets fed extruded cereals displayed significantly lower gas and SCFA levels during in vitro fermentation. Combined, 50% corn substituted with extruded corn or broken rice decreased piglet growth performance, possibly by altering their microbiota.