Biomaterial Database

[Use of fibrin glue in tracheal surgery. Experimental studies]. 1986

H Kedra

The experimental studies were undertaken in order to estimate the suitability of fibrin sealant in tracheal surgery and the compare tissue reactivity after using cyanoacrylic and fibrin adhesives. 14 piglets of the Poland white breed, weighing up to 25 kg, were used in the study. Under general tracheal anesthesis the tracheal wall was cut open by incision on the mid-line on the neck between the III-IV tubular cartilages along 3/4 of its circumference. The lips of the incision were closed by one atraumatic suture and tightened by fibrin sealant. Piglets dissecting examinations were carried out after 24 hours, 3, 7, 14, 30, 60 and 90 days after the operation. The results were estimated by macro- and microscopic studies. Comparative studies were carried out on the basis of our own similar experimental studies by means of cyanoacrylates. It was found that the Immuno fibrin adhesive is a very useful new material for tightening the tracheal wounds. The Immuno fibrin adhesive, in comparison with cyanoacrylates, has very good biological qualities, does not cause marginal tissue necrosis and increased chronic inflammatory changes. Fibrin sealant undergoes complete elimination from the wound after 7-10 days and is replaced by connective tissue.

UI	MeSH Term	Description	Entries
D003487	Cyanoacrylates	A group of compounds having the general formula CH2	Cyanoacrylate
D005337	Fibrin	A protein derived from FIBRINOGEN in the presence of THROMBIN, which forms part of the blood clot.	Antithrombin I
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001672	Biocompatible Materials	Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.	Biomaterials,Bioartificial Materials,Hemocompatible Materials,Bioartificial Material,Biocompatible Material,Biomaterial,Hemocompatible Material,Material, Bioartificial,Material, Biocompatible,Material, Hemocompatible
D013536	Suture Techniques	Techniques for securing together the edges of a wound, with loops of thread or similar materials (SUTURES).	Suture Technics,Suture Technic,Suture Technique,Technic, Suture,Technics, Suture,Technique, Suture,Techniques, Suture
D013552	Swine	Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).	Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog
D014014	Tissue Adhesives	Substances used to cause adherence of tissue to tissue or tissue to non-tissue surfaces, as for prostheses.	Adhesive, Tissue,Adhesives, Tissue,Tissue Adhesive
D014132	Trachea	The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.	Tracheas
D014945	Wound Healing	Restoration of integrity to traumatized tissue.	Healing, Wound,Healings, Wound,Wound Healings