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Chromosomal rearrangements in malignant T-cell disease frequently involve the chromosome bands containing the T-cell receptor genes. The RPMI 8402 cell line, which was established from the leukemia cells of a patient with T-cell acute lymphoblastic leukemia, is characterized by a translocation involving chromosome 14 (band q11) and chromosome 11 (band p15) [t(11;14)(p15;q11)]. By using in situ chromosomal hybridization and Southern blot analysis to examine RPMI 8402 cells, we determined that the break at 14q11 occurs within the variable region sequences of the T-cell receptor alpha-chain gene (TCRA); the break at 11p15 occurs between the HRAS1 gene and the genes for insulin and the insulin-like growth factor 2. These results suggest that the TCRA sequences activate a cellular gene located at 11p15 in malignant T-cell disorders.
M M Le Beau, and
T W McKeithan, and
E A Shima, and
R E Goldman-Leikin, and
S J Chan, and
G I Bell, and
J D Rowley, and
M O Diaz
October 1991,
Cancer genetics and cytogenetics,
M M Le Beau, and
T W McKeithan, and
E A Shima, and
R E Goldman-Leikin, and
S J Chan, and
G I Bell, and
J D Rowley, and
M O Diaz
February 1987,
Cancer,
M M Le Beau, and
T W McKeithan, and
E A Shima, and
R E Goldman-Leikin, and
S J Chan, and
G I Bell, and
J D Rowley, and
M O Diaz
May 1989,
Molecular and cellular biology,
M M Le Beau, and
T W McKeithan, and
E A Shima, and
R E Goldman-Leikin, and
S J Chan, and
G I Bell, and
J D Rowley, and
M O Diaz
May 1989,
Blood,
M M Le Beau, and
T W McKeithan, and
E A Shima, and
R E Goldman-Leikin, and
S J Chan, and
G I Bell, and
J D Rowley, and
M O Diaz
December 1998,
Oncogene,
M M Le Beau, and
T W McKeithan, and
E A Shima, and
R E Goldman-Leikin, and
S J Chan, and
G I Bell, and
J D Rowley, and
M O Diaz
September 2021,
Blood research,
M M Le Beau, and
T W McKeithan, and
E A Shima, and
R E Goldman-Leikin, and
S J Chan, and
G I Bell, and
J D Rowley, and
M O Diaz
August 1995,
Cancer genetics and cytogenetics,
M M Le Beau, and
T W McKeithan, and
E A Shima, and
R E Goldman-Leikin, and
S J Chan, and
G I Bell, and
J D Rowley, and
M O Diaz
October 2006,
Ai zheng = Aizheng = Chinese journal of cancer,
M M Le Beau, and
T W McKeithan, and
E A Shima, and
R E Goldman-Leikin, and
S J Chan, and
G I Bell, and
J D Rowley, and
M O Diaz
May 1993,
Genes, chromosomes & cancer,
M M Le Beau, and
T W McKeithan, and
E A Shima, and
R E Goldman-Leikin, and
S J Chan, and
G I Bell, and
J D Rowley, and
M O Diaz
July 1988,
Leukemia,
