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Hypo-aldosteronism has been considered an important pathophysiological mechanism in the development of hyperkalaemia. This may occur as a consequence of defective regulatory mechanisms in the plasma renin-angiotensin-aldosterone system. Two case reports of hyperkalaemia are described which illustrate the differentiation of hyperreninaemic from hyporeninaemic hypo-aldosteronism. Laboratory investigations, together with measurements of plasma renin activity and aldosterone concentrations during adrenocorticotrophic hormone stimulation and sodium depletion, demonstrated this difference. Appropriate therapy with fludrocortisone (Florinef; Squibb) and furosemide (Lasix; Hoechst) respectively returned the situation to normal.
T H Diamond, and
K R Huddle, and
A Dubb
January 1970,
L'Annee endocrinologique,
T H Diamond, and
K R Huddle, and
A Dubb
January 1995,
The British journal of clinical practice,
T H Diamond, and
K R Huddle, and
A Dubb
February 2007,
The Netherlands journal of medicine,
T H Diamond, and
K R Huddle, and
A Dubb
January 1981,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
T H Diamond, and
K R Huddle, and
A Dubb
June 1997,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
T H Diamond, and
K R Huddle, and
A Dubb
May 1984,
Postgraduate medical journal,
T H Diamond, and
K R Huddle, and
A Dubb
December 2002,
Revista medica de Chile,
T H Diamond, and
K R Huddle, and
A Dubb
November 2006,
East African medical journal,
T H Diamond, and
K R Huddle, and
A Dubb
July 2002,
The American journal of the medical sciences,
T H Diamond, and
K R Huddle, and
A Dubb
July 1965,
The Medical journal of Australia,
