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The regeneration and persistence of host- and donor-derived T cells were examined in the thymus as well as the spleen of mouse radiation bone marrow chimeras of two semiallogeneic combinations (F1----P, P----F1) with different Thy-1 markers on T cells of donor and host origins. An unexpectedly large number of host-type T cells were recovered from the spleens of F1----P chimeras, amounting to as high as 45 and 25% of total T cells at 6 and 14 weeks after bone marrow transplantation (BMT), respectively. To the contrary, the residual host-type T cells in the spleens of P----F1 chimeras disappeared quickly, resulting in less than 0.1% of total T cells at 6 weeks after BMT. It was also revealed that the number of host-type T cells in the spleens of F1----P chimeras decreased in proportion to increase of radiation dose given to the recipients.
K Hirokawa, and
T Sado, and
S Kubo, and
H Kamisaku, and
M Utsuyama
April 1992,
Transplantation,
K Hirokawa, and
T Sado, and
S Kubo, and
H Kamisaku, and
M Utsuyama
March 1986,
Cellular immunology,
K Hirokawa, and
T Sado, and
S Kubo, and
H Kamisaku, and
M Utsuyama
April 1983,
Transplantation,
K Hirokawa, and
T Sado, and
S Kubo, and
H Kamisaku, and
M Utsuyama
August 1987,
Bone marrow transplantation,
K Hirokawa, and
T Sado, and
S Kubo, and
H Kamisaku, and
M Utsuyama
August 1971,
Transplantation,
K Hirokawa, and
T Sado, and
S Kubo, and
H Kamisaku, and
M Utsuyama
July 1970,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
K Hirokawa, and
T Sado, and
S Kubo, and
H Kamisaku, and
M Utsuyama
July 1981,
Journal of immunology (Baltimore, Md. : 1950),
K Hirokawa, and
T Sado, and
S Kubo, and
H Kamisaku, and
M Utsuyama
May 1979,
Journal of immunology (Baltimore, Md. : 1950),
K Hirokawa, and
T Sado, and
S Kubo, and
H Kamisaku, and
M Utsuyama
January 1986,
Thymus,
K Hirokawa, and
T Sado, and
S Kubo, and
H Kamisaku, and
M Utsuyama
January 1984,
Thymus,
