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Fifty chronic schizophrenics were randomly assigned to a 16-week treatment either with fluspirilene or with fluphenazine decanoate. The aim of the study was to compare the antipsychotic action and the side effects of the two neuroleptics. Fluphenazine decanoate caused more side effects and the difference between the two groups was statistically significant in the items tremor, severe extrapyramidal effects and parkinsonism. More patients in the fluspirilene group (nine patients) compared with only three in the fluphenazine decanoate group remained free of side effects during the whole trial. Judged from the BPRS fluspirilene proved an equally potent neuroleptic with fluphenazine decanoate although statistically significant improvement has been obtained in more items of the scale in the fluspirilene group. The improvement in the NOSIE-30 was much more clear in the fluspirilene group. Although Clinical Global Impressions of the investigators and the nursing personnel favored fluspirilene, the differences between the two groups were not statistically significant.
H Frangos, and
N P Zissis, and
I Leontopoulos, and
N Diamantas, and
S Tsitouridis, and
I Gavriil, and
K Tsolis
November 1982,
Canadian journal of psychiatry. Revue canadienne de psychiatrie,
H Frangos, and
N P Zissis, and
I Leontopoulos, and
N Diamantas, and
S Tsitouridis, and
I Gavriil, and
K Tsolis
October 1973,
The British journal of clinical practice,
H Frangos, and
N P Zissis, and
I Leontopoulos, and
N Diamantas, and
S Tsitouridis, and
I Gavriil, and
K Tsolis
September 1970,
Diseases of the nervous system,
H Frangos, and
N P Zissis, and
I Leontopoulos, and
N Diamantas, and
S Tsitouridis, and
I Gavriil, and
K Tsolis
September 1972,
Lancet (London, England),
H Frangos, and
N P Zissis, and
I Leontopoulos, and
N Diamantas, and
S Tsitouridis, and
I Gavriil, and
K Tsolis
October 1979,
Acta psychiatrica Scandinavica,
H Frangos, and
N P Zissis, and
I Leontopoulos, and
N Diamantas, and
S Tsitouridis, and
I Gavriil, and
K Tsolis
June 1983,
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry,
H Frangos, and
N P Zissis, and
I Leontopoulos, and
N Diamantas, and
S Tsitouridis, and
I Gavriil, and
K Tsolis
August 1976,
Current therapeutic research, clinical and experimental,
H Frangos, and
N P Zissis, and
I Leontopoulos, and
N Diamantas, and
S Tsitouridis, and
I Gavriil, and
K Tsolis
May 1982,
The Journal of clinical psychiatry,
H Frangos, and
N P Zissis, and
I Leontopoulos, and
N Diamantas, and
S Tsitouridis, and
I Gavriil, and
K Tsolis
December 1994,
The American journal of psychiatry,
H Frangos, and
N P Zissis, and
I Leontopoulos, and
N Diamantas, and
S Tsitouridis, and
I Gavriil, and
K Tsolis
April 1976,
Psychopharmacology bulletin,
