-transparent.png){kind=logo}
The parasite Plasmodium falciparum, like neoplastic cells, develops resistance to multiple structurally unrelated drugs. If the mechanisms by which P. falciparum and neoplastic cells become resistant are similar, then it may be possible to reverse the resistance in the two types of cells by the same pharmacological agents. Verapamil, a calcium channel blocker, completely reversed chloroquine resistance in two chloroquine-resistant P. falciparum clones from Southeast Asia and Brazil. Verapamil reversed chloroquine resistance at the same concentration (1 X 10(-6)M) as that at which it reversed resistance in multidrug-resistant cultured neoplastic cells. This same concentration of verapamil had no effect on chloroquine-sensitive parasites. Hence, chloroquine resistance in P. falciparum may fit the criteria for the multidrug-resistant phenotype.
S K Martin, and
A M Oduola, and
W K Milhous
December 1988,
Science (New York, N.Y.),
S K Martin, and
A M Oduola, and
W K Milhous
August 2005,
International journal of antimicrobial agents,
S K Martin, and
A M Oduola, and
W K Milhous
October 1991,
Parasitology,
S K Martin, and
A M Oduola, and
W K Milhous
August 2017,
Antimicrobial agents and chemotherapy,
S K Martin, and
A M Oduola, and
W K Milhous
January 1991,
Transactions of the Royal Society of Tropical Medicine and Hygiene,
S K Martin, and
A M Oduola, and
W K Milhous
November 2001,
Antimicrobial agents and chemotherapy,
S K Martin, and
A M Oduola, and
W K Milhous
January 1990,
Lancet (London, England),
S K Martin, and
A M Oduola, and
W K Milhous
March 1993,
Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ),
S K Martin, and
A M Oduola, and
W K Milhous
April 2008,
Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases,
S K Martin, and
A M Oduola, and
W K Milhous
November 1989,
Lancet (London, England),
